A Simple and Environmentally Benign Synthetic Protocol of Indeno‐Fused Pyrido[2,3‐d]pyrimidines
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.2959
Abstract: An efficient and environmentally benign protocol for the synthesis of indeno [2ˊ,1ˊ:5,6] pyrido[2,3-d] pyrimidines has been developed. The synthesis of these pharmacologically important compounds can be achieved by the one-pot three-component condensation of 6-amino-1,3-dimethyluracil, aromatic… read more here.
Keywords: indeno; protocol; simple environmentally; environmentally benign ... See more keywords
Introduction of Poly(4-Vinylpyridine) as an Efficient Promotor for the Synthesis of Pyrano[2,3-d]Pyrimidinones and Pyrido[2,3-d]Pyrimidines
Sign Up to like & getrecommendations! Published in 2018 at "Polycyclic Aromatic Compounds"
DOI: 10.1080/10406638.2018.1524389
Abstract: Abstract This article describes an efficient method for the synthesis of pyrano[2,3-d]pyrimidinones and pyrido[2,3-d]pyrimidines via promotion of the condensation of aromatic aldehydes, malononitrile and barbituric acid and/or 6-amino-1,3-dimethyluracil in the presence of poly(4-vinylpyridine). All reactions… read more here.
Keywords: poly vinylpyridine; synthesis pyrano; pyrido pyrimidines; pyrano pyrimidinones ... See more keywords
Advances in the Chemistry of 6-6 Bicyclic Systems: Chemistry of Pyrido[3,4- d]pyrimidines.
Sign Up to like & getrecommendations! Published in 2019 at "Current organic synthesis"
DOI: 10.2174/1570179416666190704113647
Abstract: The aim of this work is to discuss the chemistry of pyrido[3,4-d]pyrimidines as one of the most important heterocyclic compounds with remarkable synthetic, biological and medical applications. In this overview, the chemistry of heterocyclic compounds… read more here.
Keywords: pyrido pyrimidine; chemistry pyrido; pyrido pyrimidines; chemistry ... See more keywords
SnAr Reactions of 2,4-Diazidopyrido[3,2-d]pyrimidine and Azide-Tetrazole Equilibrium Studies of the Obtained 5-Substituted Tetrazolo[1,5-a]pyrido[2,3-e]pyrimidines
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DOI: 10.3390/molecules27227675
Abstract: A straightforward method for the synthesis of 5-substituted tetrazolo[1,5-a]pyrido[2,3-e]pyrimidines from 2,4-diazidopyrido[3,2-d]pyrimidine in SnAr reactions with N-, O-, and S- nucleophiles has been developed. The various N- and S-substituted products were obtained with yields from 47%… read more here.
Keywords: diazidopyrido pyrimidine; substituted tetrazolo; tetrazolo pyrido; pyrido pyrimidines ... See more keywords
Exploration of Pyrido[3,4-d]pyrimidines as Antagonists of the Human Chemokine Receptor CXCR2
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DOI: 10.3390/molecules28052099
Abstract: Upregulated CXCR2 signalling is found in numerous inflammatory, autoimmune and neurodegenerative diseases, as well as in cancer. Consequently, CXCR2 antagonism is a promising therapeutic strategy for treatment of these disorders. We previously identified, via scaffold… read more here.
Keywords: exploration pyrido; pyrimidines antagonists; pyrido; cxcr2 ... See more keywords
Review on the Synthesis and Therapeutic Potential of Pyrido[2,3-d], [3,2-d], [3,4-d] and [4,3-d]pyrimidine Derivatives
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DOI: 10.3390/ph15030352
Abstract: The objective of this review is to list the structures composed of a pyridopyrimidine moiety which have shown a therapeutic interest or have already been approved for use as therapeutics. We consider all the synthetic… read more here.
Keywords: therapeutic potential; review synthesis; synthesis therapeutic; pyrimidines pyrido ... See more keywords