Synthesis of β-Lactam-containing Pyrido[3′,2′:4,5]thieno[3,2-e][1,4]diazepines
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DOI: 10.1002/jhet.2936
Abstract: Novel tricyclic 1,4-diazepine derivatives – pyrido[3′,2′:4,5]thieno[3,2-e][1,4]diazepin-2-ones – have been synthesized. Azetidin-2-one moiety has been incorporated into the 1,4-diazepine scaffold by [2 + 2]cycloaddition of functionalized ketenes to imine C═N bond, and several tetracyclic azetodiazepines which can be… read more here.
Keywords: chemistry; synthesis lactam; containing pyrido; thieno diazepines ... See more keywords
Synthesis and characterization of new pyrido-thieno-pyrimidine derivatives incorporating pyrazole moiety
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DOI: 10.1080/00397911.2017.1370113
Abstract: ABSTRACT 2-Hydrazinyl-pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-one was reacted with commercially available active methylene compounds (e.g., acetylacetone, ethyl acetoacetate, and diethyl malonate) and ethoxymethylenemalononitrile to afford the respective pyrazole derivatives. Moreover, the prepared pyrazolinone was utilized for synthesis of some… read more here.
Keywords: characterization new; pyrido thieno; synthesis characterization; pyrido ... See more keywords
Facile synthesis and characterization of novel pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-one and pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidine incorporating 1,3-diarylpyrazole moiety
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DOI: 10.1080/00397911.2018.1468911
Abstract: Abstract 4-(3-(4-Hydroxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-6-phenyl-2-thioxo-1,2-di hydro-pyridine-3-carbonitrile (1) reacted with ethyl chloroacetate (2) in ethanolic sodium acetate solution to yield the corresponding ethyl (3-cyanopyridin-2-ylsulphanyl)acetate derivative 3. Intramolecular cyclization of compound 3 was achieved by its heating in DMF containing… read more here.
Keywords: pyrido pyrazolo; pyrimidin one; pyrido thieno; pyrazolo ... See more keywords
New heterocyclic systems: Pyrido[2′,3′:5,4]thieno(furo)[3,2-d]oxazines as intermediate compounds for the synthesis of substituted pyrido[3′,2′:4,5]thieno(furo)[3,2-d]pyrimidines
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DOI: 10.1080/00397911.2019.1644656
Abstract: Abstract Starting from the ethyl 1-aminothieno(furo)[2,3-b]pyridine-2-carboxylates 1 by alkaline hydrolysis the corresponding potassium salts of thieno(furo)[2,3-b]pyridines 2 were obtained. Ongoing to the relevant acids (by treatment with hydrochloric acid), we have observed that while thieno[2,3-b]pyridines… read more here.
Keywords: thieno furo; furo; pyrido thieno; new heterocyclic ... See more keywords