Recent advances in chemistry and pharmacological aspects of 2-pyridone scaffolds
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Saudi Chemical Society"
DOI: 10.1016/j.jscs.2021.101259
Abstract: Abstract Background The chemistry and applications of 2-pyridone structures have recently attracted a lot of attention due to their uses as synthetic intermediates and their biological importance. Furthermore, 2-pyridones are a different category of pharmacophores… read more here.
Keywords: advances chemistry; chemistry pharmacological; recent advances; pyridone ... See more keywords
Inhibition of SARS-CoV-2 main protease 3CLpro by means of α-ketoamide and pyridone-containing pharmaceuticals using in silico molecular docking
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.128878
Abstract: Abstract The coronavirus disease infections (COVID-19) caused by a new type of coronavirus (SARS-CoV-2) have been emerging in the entire world. Therefore, it is necessary to find out potential therapeutic pharmaceuticals for this disease. This… read more here.
Keywords: containing pharmaceuticals; protease; pyridone containing; sars cov ... See more keywords
A series of new polycyclic carbamoyl pyridone analogues were synthesized by using chloroacetaldehyde as a substrate
Sign Up to like & getrecommendations! Published in 2021 at "Tetrahedron"
DOI: 10.1016/j.tet.2021.132156
Abstract: Abstract A facile, universal and economical method was developed for the synthesis of polycyclic carbamyl pyridone analogues of Baloxavir marboxil from the cyclization of chloroacetaldehyde with o-aminoamide derivatives. In this method, without any other catalysts… read more here.
Keywords: pyridone analogues; polycyclic carbamoyl; carbamoyl pyridone; pyridone ... See more keywords
Hydroxypyridine/Pyridone Interconversions within Ruthenium Complexes and Their Application in the Catalytic Hydrogenation of CO2.
Sign Up to like & getrecommendations! Published in 2023 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.3c00287
Abstract: Reaction of a new ligand 6-DiPPon (6-diisopropylphosphino-2-pyridone) with 0.5 equiv of [RuCl2(p-cymene)]2 resulted in the formation of a mixture of [RuCl2(p-cymene)(κ1-P-6-DiPPon)]2 (1) and [RuCl(p-cymene)(κ2-P,N-6-DiPPin)]Cl ([2]Cl) (where 6-DiPPin = 6-diisopropylphosphino-2-hydroxypyridine). The ratio between the two products… read more here.
Keywords: dippon; ruthenium complexes; pyridone; cymene ... See more keywords
Biosynthesis of Calipyridone A Represents a Fungal 2-Pyridone Formation without Ring Expansion in Aspergillus californicus.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.1c03792
Abstract: A chemical investigation of the filamentous fungus Aspergillus californicus led to the isolation of a polyketide-nonribosomal peptide hybrid, calipyridone A (1). A putative biosynthetic gene cluster cpd for production of 1 was next identified by… read more here.
Keywords: calipyridone; aspergillus californicus; fungal pyridone; pyridone ... See more keywords
Directed Zincation or Magnesiation of the 2-Pyridone and 2,7-Naphthyridone Scaffold Using TMP Bases.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b02690
Abstract: A regioselective zincation of the 2-pyridone and 2,7-naphthyridone scaffolds has been developed. Zincations of the methoxyethoxymethyl (MEM)-protected compounds using TMP2Zn·2MgCl2·2LiCl (TMP = 2,2,6,6-tetramethylpiperidyl) followed by trapping with electrophiles provided functionalized 2-pyridones and 2,7-naphthyridones. I/Mg exchange… read more here.
Keywords: tmp; pyridone naphthyridone; zincation; magnesiation pyridone ... See more keywords
Bioactive 2-pyridone-containing heterocycle syntheses using multicomponent reactions
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra07056a
Abstract: 2-Pyridone-containing heterocycles are considered privileged scaffolds in drug discovery due to their behavior as hydrogen bond donors and/or acceptors and nonpeptidic mimics, and remarkable physicochemical properties such as metabolic stability, solubility in water, and lipophilicity.… read more here.
Keywords: multicomponent reactions; pyridone containing; pyridone; bioactive pyridone ... See more keywords
Influence of substituents and cooperativity in doubly hydrogen-bonded complexes of 2-pyridone and oxalic acid
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Physics"
DOI: 10.1080/00268976.2018.1459918
Abstract: ABSTRACT We performed a systemic investigation of the substitution and cooperative effects on the O–H···O and N–H···O H-bonds in the complexes of 2-pyridone and its derivatives with oxalic acid. Generally, the electron-withdrawing substituent in 2-pyridone… read more here.
Keywords: influence substituents; bond; oxalic acid; complexes pyridone ... See more keywords
A Highly Substituted Ring-Fused 2-Pyridone Compound Targeting PrfA and the Efflux Regulator BrtA in Listeria monocytogenes
Sign Up to like & getrecommendations! Published in 2023 at "mBio"
DOI: 10.1128/mbio.00449-23
Abstract: Bacteria resistant to one or several antibiotics are a very large problem, threatening not only treatment of infections but also surgery and cancer treatments. Thus, new types of antibacterial drugs are desperately needed. ABSTRACT Listeria… read more here.
Keywords: ring fused; pyridone; cholic acid; listeria monocytogenes ... See more keywords
X-RAY PHOTOELECTRON SPECTROSCOPY INVESTIGATION OF NITROGEN TRANSFORMATION IN CHINESE OIL SHALES DURING PYROLYSIS
Sign Up to like & getrecommendations! Published in 2017 at "Oil Shale"
DOI: 10.3176/oil.2017.2.03
Abstract: X-ray photoelectron spectroscopy (XPS) was used to investigate changes in nitrogen functionalities present in Chinese Huadian (HD), Maoming (MM) and Yaojie (YJ) oil shales during pyrolysis. Throughout the process (T ≤ 600 °C), most of… read more here.
Keywords: nitrogen; spectroscopy; oil shale; pyridone ... See more keywords
Thermal and Emission Properties of a Series of Lanthanides Complexes with N-Biphenyl-Alkylated-4-Pyridone Ligands: Crystal Structure of a Terbium Complex with N-Benzyl-4-Pyridone
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26072017
Abstract: This work focuses on the investigation of the liquid crystalline behavior and luminescence properties of the lanthanide complexes of Eu(III), Sm(III) and Tb(III) with N-biphenyl-alkylated-4-pyridone ligands. The organic ligands having a biphenyl group attached via… read more here.
Keywords: biphenyl alkylated; alkylated pyridone; pyridone ligands; iii iii ... See more keywords