Inhibition of SARS-CoV-2 main protease 3CLpro by means of α-ketoamide and pyridone-containing pharmaceuticals using in silico molecular docking
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.128878
Abstract: Abstract The coronavirus disease infections (COVID-19) caused by a new type of coronavirus (SARS-CoV-2) have been emerging in the entire world. Therefore, it is necessary to find out potential therapeutic pharmaceuticals for this disease. This… read more here.
Keywords: containing pharmaceuticals; protease; pyridone containing; sars cov ... See more keywords
Bioactive 2-pyridone-containing heterocycle syntheses using multicomponent reactions
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DOI: 10.1039/d2ra07056a
Abstract: 2-Pyridone-containing heterocycles are considered privileged scaffolds in drug discovery due to their behavior as hydrogen bond donors and/or acceptors and nonpeptidic mimics, and remarkable physicochemical properties such as metabolic stability, solubility in water, and lipophilicity.… read more here.
Keywords: multicomponent reactions; pyridone containing; pyridone; bioactive pyridone ... See more keywords