Structural attributes and substrate specificity of pyridoxal kinase from Leishmania donovani.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.02.257
Abstract: The enzyme pyridoxal kinase (PdxK) catalyzes the conversion of pyridoxal to pyridoxal-5'-phosphate using ATP as the co-factor. The product pyridoxal-5'-phosphate (PLP) plays a key role in several biological processes such as transamination, decarboxylation and deamination.… read more here.
Keywords: leishmania donovani; pyridoxal kinase; pyridoxal; ldpdxk ... See more keywords
Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers
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DOI: 10.1080/2162402x.2021.1950954
Abstract: ABSTRACT Malignant cells adapt to the hostile tumor microenvironment by escaping from, or actively suppressing, anticancer immune responses. In the past, we reported that reduced synthesis of active vitamin B6 (due to downregulation of pyridoxal… read more here.
Keywords: microenvironment; adp ribose; poly adp; pyridoxal kinase ... See more keywords
Thiamine‐dependent regulation of mammalian brain pyridoxal kinase in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15576
Abstract: Vitamins B1 (thiamine) and B6 (pyridox (al/ine/amine)) are crucial for central nervous system (CNS) function and neurogenesis due to the coenzyme action of their phosphorylated derivatives in the brain metabolism of glucose and neurotransmitters. Here,… read more here.
Keywords: vitro vivo; thiamine; pyridoxal kinase; pdxk ... See more keywords