A direct enzymatic evaluation platform (DEEP) to fine‐tuning pyridoxal 5′‐phosphate‐dependent proteins for cadaverine production
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28270
Abstract: Pyridoxal 5′‐phosphate (pyridoxal phosphate, PLP) is an essential cofactor for multiple enzymatic reactions in industry. However, cofactor engineering based on PLP regeneration and related to the performance of enzymes in chemical production has rarely been… read more here.
Keywords: phosphate; evaluation platform; pyridoxal phosphate; enzymatic evaluation ... See more keywords
Vitamin B6 deficiency with normal plasma levels of pyridoxal 5'-phosphate in perinatal hypophosphatasia.
Sign Up to like & getrecommendations! Published in 2021 at "Bone"
DOI: 10.1016/j.bone.2021.116007
Abstract: Pyridoxal 5'-phosphate (PLP), the principal circulating form of vitamin B6 (B6), is elevated in the plasma of individuals with hypophosphatasia (HPP). HPP is the inborn-error-of-metabolism caused by loss-of-function mutation(s) of ALPL, the gene that encodes… read more here.
Keywords: plp; plasma; level; pyridoxal phosphate ... See more keywords
Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity.
Sign Up to like & getrecommendations! Published in 2018 at "Cell metabolism"
DOI: 10.1016/j.cmet.2018.04.009
Abstract: Kidney cancer, one of the ten most prevalent malignancies in the world, has exhibited increased incidence over the last decade. The most common subtype is "clear cell" renal cell carcinoma (ccRCC), which features consistent metabolic… read more here.
Keywords: carcinoma; arginase; biosynthetic cofactor; pyridoxal phosphate ... See more keywords
Increase of gamma-aminobutyric acid contents in rice embryo with protein hydrolysates and pyridoxal-5-phosphate using abiotic stress
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cereal Science"
DOI: 10.1016/j.jcs.2019.102803
Abstract: Abstract Effects of abiotic stress treatment and the addition of protein hydrolysates and pyridoxal-5-phosphate on the gamma-aminobutyric acid (GABA) accumulation in rice embryo were investigated. After adjusting the moisture content to 20% by adding an… read more here.
Keywords: pyridoxal phosphate; hydrolysates pyridoxal; abiotic stress; rice embryo ... See more keywords
Spatial structure and conformations of hydrazones derived from pyridoxal 5'-phosphate and 2-, 3-pyridinecarbohydrazide in the light of NMR study and quantum chemical calculations
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2021.117372
Abstract: Abstract Coordination properties and biological activity of the compounds depend significantly on their capability of taking the conformation, most appropriate for complex formation or binding to the target biomolecule. The hydrazones formed by B6 vitamers,… read more here.
Keywords: derived pyridoxal; hydrazones derived; phosphate pyridinecarbohydrazide; pyridoxal phosphate ... See more keywords
Hyperconjugation Promotes Catalysis in a Pyridoxal 5′-Phosphate-Dependent Enzyme
Sign Up to like & getrecommendations! Published in 2018 at "ACS Catalysis"
DOI: 10.1021/acscatal.8b01911
Abstract: Pyridoxal 5′-phosphate (PLP)-dependent enzymes facilitate reaction specificity by aligning the scissile σ-bond of the PLP-substrate covalent complex perpendicular to the ring of the cofactor. Current models propose that this alignment causes a destabilization of the… read more here.
Keywords: catalysis pyridoxal; pyridoxal phosphate; promotes catalysis; hyperconjugation promotes ... See more keywords
Catalytic Roles of Coenzyme Pyridoxal-5'-phosphate (PLP) in PLP-dependent Enzymes: Reaction Pathway for Methionine-γ-lyase-catalyzed L-methionine Depletion.
Sign Up to like & getrecommendations! Published in 2020 at "ACS catalysis"
DOI: 10.1021/acscatal.9b03907
Abstract: Pyridoxal-5'-phosphate (PLP), the active form of vitamin B6, is an important and versatile coenzyme involved in a variety of enzymatic reactions, accounting for about 4% of all classified activities. However, the detailed catalytic reaction pathways… read more here.
Keywords: plp; phosphate plp; pyridoxal phosphate; dependent enzymes ... See more keywords
Snapshots of the Catalytic Cycle of an O2, Pyridoxal Phosphate-Dependent Hydroxylase.
Sign Up to like & getrecommendations! Published in 2018 at "ACS chemical biology"
DOI: 10.1021/acschembio.8b00039
Abstract: Enzymes that catalyze hydroxylation of unactivated carbons normally contain heme and nonheme iron cofactors. By contrast, how a pyridoxal phosphate (PLP)-dependent enzyme could catalyze such a hydroxylation was unknown. Here, we investigate RohP, a PLP-dependent… read more here.
Keywords: snapshots catalytic; plp dependent; pyridoxal phosphate; catalytic cycle ... See more keywords
Pyridoxal 5’-phosphate synthesis and salvage in Bacteria and Archaea: predicting pathway variant distributions and holes
Sign Up to like & getrecommendations! Published in 2023 at "Microbial Genomics"
DOI: 10.1099/mgen.0.000926
Abstract: Pyridoxal 5’-phosphate or PLP is a cofactor derived from B6 vitamers and essential for growth in all known organisms. PLP synthesis and salvage pathways are well characterized in a few model species even though key… read more here.
Keywords: phosphate synthesis; synthesis salvage; plp synthesis; synthesis ... See more keywords
Genetic Analysis Using Vitamin B6 Antagonist 4-Deoxypyridoxine Uncovers a Connection between Pyridoxal 5′-Phosphate and Coenzyme A Metabolism in Salmonella enterica
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bacteriology"
DOI: 10.1128/jb.00607-21
Abstract: PLP is a ubiquitous cofactor required by enzymes in diverse metabolic networks. The data presented here expand our understanding of the toxic effects of dPN, a vitamin B6 antagonist that is often used to mimic… read more here.
Keywords: study; deoxypyridoxine; pyridoxal phosphate; metabolism ... See more keywords
The Schiff bases of pyridoxal-5-phosphate and hydrazides of certain pyrazoles: Stability, kinetics of formation, and synthesis
Sign Up to like & getrecommendations! Published in 2017 at "Russian Journal of General Chemistry"
DOI: 10.1134/s1070363217060093
Abstract: The interaction of pyridoxal-5-phosphate with 3-methyl-1Н-pyrazole-5-carbohydrazide, 2-(3,5-dimethyl-1Н-pyrazol-4-yl)acetohydrazide, and 1Н-pyrazole-3-carbohydrazide has yielded Schiff bases; the products have been characterized by 1Н NMR and IR spectra. The binding ability of these pyrazoles with respect to pyridoxal-5-phosphate under… read more here.
Keywords: schiff bases; phosphate hydrazides; formation; pyridoxal phosphate ... See more keywords