Pyridoxine‐Dependent Epilepsy: A Treatable Epilepsy Syndrome Presenting with Dystonia and Congenital Cataracts with a Novel Mutation
Sign Up to like & getrecommendations! Published in 2022 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.13651
Abstract: Pyridoxine-dependent epilepsy (PDE; MIM#266100), an early-onset epileptic encephalopathy, is an autosomal recessive inborn error of pyridoxine (vitamin B6) metabolism. PDE is due to mutations in the ALDH7A1 gene (MIM*107323) on chromo-some 5q31, fi rst described… read more here.
Keywords: dependent epilepsy; congenital cataracts; pde; epilepsy ... See more keywords
Pyridoxine‐responsive KCNQ2 epileptic encephalopathy: Additional cases and literature review
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.2024
Abstract: Typical patients with KCNQ2 (OMIM# 602235) epileptic encephalopathy present early neonatal‐onset intractable seizures with a burst suppression EEG pattern and severe developmental delay or regression, and those patients always fail first‐line treatment with sodium channel… read more here.
Keywords: kcnq2 epileptic; encephalopathy additional; responsive kcnq2; epileptic encephalopathy ... See more keywords
Increased leptin-b expression and metalloprotease expression contributed to the pyridoxine-associated toxicity in zebrafish larvae displaying seizure-like behavior.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114294
Abstract: Epilepsy is a common neurological disorder affecting people of all ages, races and ethnic backgrounds world-wide. Vitamin B6 supplementation has been widely used as an adjuvant for treating epilepsy. However, the adverse effects, including nausea… read more here.
Keywords: pyridoxine; associated toxicity; increased leptin; larvae displaying ... See more keywords
Folate and pyridoxine to ssri in major depression and residual cognitive Decline
Sign Up to like & getrecommendations! Published in 2017 at "European Psychiatry"
DOI: 10.1016/j.eurpsy.2017.01.752
Abstract: Introduction Depressive disorders are very common conditions, lifetime risk for experiencing major depression is approximately 15%. Objective Patients with major depression having an insufficient response to SSRI may benefit from addition of methylfolate and pyridoxine.… read more here.
Keywords: pyridoxine; depression; major depression; folate pyridoxine ... See more keywords
Design, synthesis, biological evaluation and molecular docking study of novel pyridoxine–triazoles as anti-Alzheimer's agents
Sign Up to like & getrecommendations! Published in 2020 at "RSC Advances"
DOI: 10.1039/d0ra04942e
Abstract: A series of multi-target natural product-pyridoxine based derivatives were designed, synthesized, characterized and evaluated as anti-Alzheimer agents. In vitro testing revealed the multi-functional properties of compounds such as inhibition of acetylcholinesterase (AChE), antioxidant and metal… read more here.
Keywords: pyridoxine; design synthesis; ache; anti alzheimer ... See more keywords
Antiquitin Deficiency with Adolescent Onset Epilepsy: Molecular Diagnosis in a Mother of Affected Offsprings.
Sign Up to like & getrecommendations! Published in 2018 at "Neuropediatrics"
DOI: 10.1055/s-0037-1621721
Abstract: Antiquitin deficiency is the most prevalent form of pyridoxine-dependent epilepsy. While most patients present with neonatal onset of therapy-resistant seizures, a few cases with late-onset during infancy have been described. Here, we describe the juvenile… read more here.
Keywords: pyridoxine; diagnosis; onset epilepsy; antiquitin deficiency ... See more keywords
Dietary pyridoxine requirement of fingerling Channa punctatus (Bloch) based on growth performance, liver pyridoxine concentration, and carcass composition
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Applied Aquaculture"
DOI: 10.1080/10454438.2018.1456999
Abstract: ABSTRACT Seven casein gelatin-based diets containing 450 g/kg CP and 18.39 kJ/g GE with different levels of pyridoxine (0, 2, 4, 6, 8, 10, and 12 mg/kg diet) were fed to fingerling Channa punctatus (4.66… read more here.
Keywords: pyridoxine; pyridoxine requirement; liver pyridoxine; fingerling channa ... See more keywords
A possible ocular biomarker for response to hyperornithinemia in gyrate atrophy: the effect of pyridoxine, lysine, and arginine-restricted diet in a patient with advanced disease
Sign Up to like & getrecommendations! Published in 2022 at "Ophthalmic Genetics"
DOI: 10.1080/13816810.2022.2098986
Abstract: ABSTRACT Background Loss of function variants in the ornithine aminotransferase (OAT) gene cause accumulation of ornithine levels, leading to gyrate atrophy. The benefit of ornithine-lowering therapies has been documented in a mouse model and young… read more here.
Keywords: ornithine; ornithine levels; pyridoxine; gyrate atrophy ... See more keywords
Diagnosis of pyridoxine‐dependent epilepsy in an adult presenting with recurrent status epilepticus
Sign Up to like & getrecommendations! Published in 2019 at "Epilepsia"
DOI: 10.1111/epi.16408
Abstract: Pyridoxine‐dependent epilepsy (PDE) is a genetic metabolic disease caused by inborn errors affecting vitamin B6 metabolism, which typically presents with neonatal seizures resistant to antiepileptic drugs (AEDs). Treatment with pyridoxine terminates seizures and prevents neurological… read more here.
Keywords: pyridoxine; epilepsy; dependent epilepsy; diagnosis pyridoxine ... See more keywords
Is pyridoxine effective and safe for post‐partum lactation inhibition? A systematic review
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Pharmacy and Therapeutics"
DOI: 10.1111/jcpt.12526
Abstract: It has been suggested that pyridoxine has an antilactogenic effect. Studies of the efficacy of pyridoxine in suppressing lactation have reported conflicting results. The aim of this review was to evaluate the effectiveness and safety… read more here.
Keywords: pyridoxine; post partum; partum lactation; lactation inhibition ... See more keywords
Effects of Vitamin B6 (Pyridoxine) and a B Complex Preparation on Dreaming and Sleep
Sign Up to like & getrecommendations! Published in 2018 at "Perceptual and Motor Skills"
DOI: 10.1177/0031512518770326
Abstract: Anecdotal evidence indicates that supplementation with vitamin B6 (pyridoxine) before bed can enhance dream vividness and recall. In a single pilot study, Ebben, Lequerica, and Spielman (2002) found that vitamin B6 had a dose-dependent effect… read more here.
Keywords: pyridoxine; dream; complex preparation; vitamin pyridoxine ... See more keywords