Electrochemical detection of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone using a cytochrome P450 2E1 decorated biosensor
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Electroanalytical Chemistry"
DOI: 10.1016/j.jelechem.2018.03.038
Abstract: Abstract In this work, a novel electrochemical biosensor for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) was developed based on cytochrome P450 2E1 (CYP2E1). The biosensor was fabricated by immobilization of CYP2E1 with poly (diallyldimethylammonium chloride) (PDDA) - poly (sodium-p-styrenesulfonate)… read more here.
Keywords: detection; biosensor; p450 2e1; pyridyl butanone ... See more keywords
Acrolein Increases the Pulmonary Tumorigenic Activity of the Tobacco-Specific Nitrosamine 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
Sign Up to like & getrecommendations! Published in 2022 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.2c00135
Abstract: Tobacco smoke is a complex mixture of more than 7000 chemicals, of which many are toxic and/or carcinogenic. Many hazard assessments of tobacco have focused on individual chemical exposures without consideration of how the chemicals… read more here.
Keywords: nnk acrolein; methylnitrosamino pyridyl; tobacco; pyridyl butanone ... See more keywords
Molecular Basis for Metabolic Regioselectivity and Mechanism of Cytochrome P450s toward Carcinogenic 4-(Methylnitrosamino)-(3-pyridyl)-1-butanone (NNK).
Sign Up to like & getrecommendations! Published in 2019 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.9b00353
Abstract: As an abundantly present tobacco component, carcinogen 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanone (NNK) has also been detected in atmospheric particulate matter, suggesting the ineluctable exposure risk of this contaminant. NNK metabolic activation by cytochrome P450 enzymes (CYPs) is… read more here.
Keywords: mechanism; regioselectivity; pyridyl butanone; butanone nnk ... See more keywords
Physico-chemical properties of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) diazonium ion: a theoretical investigation
Sign Up to like & getrecommendations! Published in 2021 at "RSC Advances"
DOI: 10.1039/d1ra04343a
Abstract: NNKDI TCTT molecular orbital energies (a), molecular orbitals 46 (HOMO), 47 (LUMO) and 48 (LUMO+1) as calculated at the B3LYP/6-311G** level of theory. read more here.
Keywords: properties methylnitrosamino; chemical properties; pyridyl butanone; butanone nnk ... See more keywords