N-Heterocyclic 3-Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia.
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DOI: 10.1021/acs.jmedchem.2c00788
Abstract: Acute myelogenous leukemia (AML), a disease of the blood and bone marrow, is characterized by the inability of myeloblasts to differentiate into mature cell types. Dihydroorotate dehydrogenase (DHODH) is an enzyme well-known in the pyrimidine… read more here.
Keywords: myelogenous leukemia; acute myelogenous; pyridyl carboxamide; dhodh ... See more keywords