Pyridylpiperazine-based allosteric inhibitors of RND-type multidrug efflux pumps
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-021-27726-2
Abstract: Efflux transporters of the RND family confer resistance to multiple antibiotics in Gram-negative bacteria. Here, we identify and chemically optimize pyridylpiperazine-based compounds that potentiate antibiotic activity in E. coli through inhibition of its primary RND… read more here.
Keywords: pyridylpiperazine based; allosteric inhibitors; based allosteric; rnd type ... See more keywords