DFT and single crystal analysis of the pyrimethamine-based novel co-crystal salt: 2,4-diamino-5-(4-chloro-phenyl)-6-ethylpyrimidin-1-ium:4-hydroxybenzoate:methanol:hydrate (1:1:1:1) (DEHMH)
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.127041
Abstract: Abstract The present work is related to the synthesis, single crystal analysis, and computational investigation of pyrimethamine co-crystal salt with 4-hydroxybenzoic acid in methanol. The study shows that hydrogen bonding interactions are responsible for the… read more here.
Keywords: pyrimethamine; single crystal; crystal salt; crystal ... See more keywords
Long-Term Low-Dose Pyrimethamine Use for the Prevention of Ocular Toxoplasmosis Recurrences: A Cohort Study
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DOI: 10.1080/09273948.2024.2321270
Abstract: ABSTRACT Purpose To describe the effect of long-term, low-dose pyrimethamine for the prevention of ocular toxoplasmosis (OT) recurrences. Methods Sixty-three consecutive patients with inactive ocular toxoplasmosis and positive toxoplasma IgG serology were included. Pyrimethamine (25 mg) + folinic… read more here.
Keywords: low dose; long term; term low; pyrimethamine ... See more keywords
Study of anti-Toxoplasma gondii effect of mPEG–PCL copolymeric loaded with pyrimethamine, in vitro
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DOI: 10.1186/s13568-025-01876-8
Abstract: The discovery of new drugs with minimal toxicity is crucially important in the search for effective treatments for toxoplasmosis. The study aimed to assess the effectiveness of pyrimethamine-loaded mPEG–PCL copolymeric nanoparticles (mPEG–PCL–Pyr) against Toxoplasma gondii… read more here.
Keywords: pcl copolymeric; pyrimethamine; study; mpeg pcl ... See more keywords
Stability of a pyrimethamine suspension compounded from bulk powder
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DOI: 10.2146/ajhp160551
Abstract: Purpose. Development of a stability‐indicating high‐performance liquid chromatography (HPLC) method for pyrimethamine analysis, with subsequent application of that method to assess the 90‐day stability of a pyrimethamine suspension compounded from bulk USP‐grade pyrimethamine powder, is… read more here.
Keywords: stability pyrimethamine; pyrimethamine suspension; pyrimethamine; powder ... See more keywords