Evaluation and structure-activity relationship analysis of a new series of 4-imino-5H-pyrazolo[3,4-d]pyrimidin-5-amines as potential antibacterial agents
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DOI: 10.1016/j.molstruc.2017.05.050
Abstract: Abstract The synthesis of pyrazolo[3,4- d ]pyrimidine derivatives is important due to their presence in various biologically active compounds such as anticancer, antimicrobial, antiparasitic, anti-inflammatory and antidiabetic agents. In this project, a new and efficient… read more here.
Keywords: pyrazolo pyrimidin; pyrimidin amines; relationship; imino pyrazolo ... See more keywords
A Microwave-Enhanced Synthesis and Biological Evaluation of N-Aryl‑5,6,7,8‑tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amines
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Brazilian Chemical Society"
DOI: 10.21577/0103-5053.20190044
Abstract: A series of N-aryl-5,6,7,8-tetra-hydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-amines were synthesized in moderate to good yield by using a microwave-enhanced conditions. The selected compounds were evaluated for their cytotoxic effects (IC50 values) on human pulmonary carcinoma (A549), murine BALB/c spontaneous… read more here.
Keywords: microwave enhanced; aryl; thieno pyrimidin; pyrimidin amines ... See more keywords