Synthesis and biological evaluation of N4 -hydrazone derivatives of 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one as novel anticancer agents with antimetastatic adjunct efficacy.
Sign Up to like & getrecommendations! Published in 2021 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202100213
Abstract: To obtain new anticancer agents with antimetastatic adjunct efficacy, a series of novel N4 -hydrazone derivatives of 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one were designed and synthesized by an eight-step reaction, with appropriate yields. All the synthesized compounds were evaluated… read more here.
Keywords: pyrimidin one; pyrrolo pyrimidin; dihydro pyrrolo; adjunct efficacy ... See more keywords
Physicochemical properties and antimicrobial activity of new spirocyclic thieno[2,3-d]pyrimidin-4(3H)-one derivatives
Sign Up to like & getrecommendations! Published in 2017 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-017-2057-1
Abstract: A number of 6'-methylidene-2,3-dihydro-1H-spiro[pyridine-4,5'-thieno[2,3-d]pyrimidin]-4'(3'H)-one derivatives, obtained as major products of a domino reaction between 5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidines and electron-deficient alkynes, were characterized for their acid-base properties and lipophilicity and evaluated for the antimicrobial activity against a number… read more here.
Keywords: one derivatives; thieno; pyrimidin one; antimicrobial activity ... See more keywords
Synthesis of arylidene hydrazinylpyrido[2,3-d]pyrimidin-4-ones as potent anti-microbial agents
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DOI: 10.1016/j.heliyon.2020.e04956
Abstract: Combination of arylidene hydrazinyl moiety with pyrido[2,3-d]pyrimidin-4-one skeleton in compounds 7‒26 results in the output of unprecedented anti-microbial agents. Arylidene hydrazinyl based on Pyrido[2,3-d]pyrimidin-4-one analoges 7‒26 prepared by the treatment of [2,3-d]pyrimidin-4-ones 6a,b with various… read more here.
Keywords: pyrimidin; pyrimidin ones; anti microbial; pyrimidin one ... See more keywords
Redox- and thermally-induced linkage isomerization of thieno[2,3-d]pyrimidin-4-one pentacyanoferrate(II/III) complexes
Sign Up to like & getrecommendations! Published in 2019 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2019.02.005
Abstract: Abstract Thieno[2,3-d]pyrimidin-4-one (LN,S) and pyrimidone (LN) pentacyanoferrate(II/III) complexes, [FeII/III(CN)5(L)]3−/2−, were prepared in H2O/DMF (3:1) solutions and characterized by spectroscopic (UV–vis), electrochemical (cyclic voltammetry), and spectroelectrochemical techniques. Results indicate a slight preference of iron(II) to coordination… read more here.
Keywords: iii; pyrimidin one; pentacyanoferrate iii; isomerization ... See more keywords
Synthesis, Crystal structure, Hirshfeld surface Analysis and computational approach of new 2-methylbenzimidazo[1,2-a]pyrimidin-4(1H)-one
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.130497
Abstract: ABSTRACT The present article describes the synthesis of the new compound 2-methylbenzimidazo[1,2-a]pyrimidin-4(1H)-one. The electronic and spatial structure of this molecule was studied theoretically and experimentally. The title molecule, C11H9N3O, is slightly twisted and bowed based… read more here.
Keywords: methylbenzimidazo pyrimidin; surface analysis; pyrimidin one; structure ... See more keywords
Inactivating Activities and Mechanism of Imidazo[1,2-c]pyrimidin-5(6H)-one Nucleoside Derivatives Incorporating a Sulfonamide Scaffold.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c08129
Abstract: Twenty-eight imidazo[1,2-c]pyrimidin-5(6H)-one nucleoside derivatives incorporating a sulfonamide scaffold with preferable inactivating activities on pepper mild mottle virus (PMMoV) were designed and synthesized. Then, compound B29 with illustrious inactivating activity against PMMoV was received on the… read more here.
Keywords: nucleoside derivatives; derivatives incorporating; pmmov; imidazo pyrimidin ... See more keywords
Facile synthesis and characterization of novel pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4(3H)-one and pyrido[2′,3′:3,4]pyrazolo[1,5-a]pyrimidine incorporating 1,3-diarylpyrazole moiety
Sign Up to like & getrecommendations! Published in 2018 at "Synthetic Communications"
DOI: 10.1080/00397911.2018.1468911
Abstract: Abstract 4-(3-(4-Hydroxyphenyl)-1-phenyl-1H-pyrazol-4-yl)-6-phenyl-2-thioxo-1,2-di hydro-pyridine-3-carbonitrile (1) reacted with ethyl chloroacetate (2) in ethanolic sodium acetate solution to yield the corresponding ethyl (3-cyanopyridin-2-ylsulphanyl)acetate derivative 3. Intramolecular cyclization of compound 3 was achieved by its heating in DMF containing… read more here.
Keywords: pyrido pyrazolo; pyrimidin one; pyrido thieno; pyrazolo ... See more keywords
Synthesis of 3-oxoesters and functional derivatives of pyrimidin-4(3Н)-one based on 1-(2,6-dihalophenyl)cyclopropan-1-carboxylic acids
Sign Up to like & getrecommendations! Published in 2017 at "Russian Journal of General Chemistry"
DOI: 10.1134/s1070363217020128
Abstract: Special features of the synthesis and chemical transformations of novel functional derivatives of 6-[1-(2,6-dihalophenyl)cyclopropyl]pyrimidin-4(3H)-one and ethyl esters of 3-[1-(2,6-dihalophenyl)cyclopropyl]-2-methyl-3-oxopropanoic acids prepared from 2-(2,6-dihalophenyl)acetonitriles have been revealed. Novel achiral structural analogs of experimental anti-HIV agent МС-1501… read more here.
Keywords: functional derivatives; synthesis oxoesters; pyrimidin one; oxoesters functional ... See more keywords
From Serendipity to Rational Identification of the 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one Core as a New Chemotype of AKT1 Inhibitors for Acute Myeloid Leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14112295
Abstract: Acute myeloid leukemia (AML) is a heterogeneous hematopoietic malignancy whose prognosis is globally poor. In more than 60% of AML patients, the PI3K/AKTs/mTOR signaling pathway is aberrantly activated because of oncogenic driver alterations and further… read more here.
Keywords: myeloid leukemia; tetrahydrobenzo thieno; acute myeloid; rational identification ... See more keywords