Synthesis of pyrazolo[3,4-d]pyrimidin-4(5H)-ones tethered to 1,2,3-triazoles and their evaluation as potential anticancer agents.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.06.055
Abstract: A series of hybrid aza heterocycles containing pyrazolo[3,4-d]pyrimidin-4(5H)-ones tethered to 1,2,3-triazole scaffold were synthesized from 1,3-dipolar cycloaddition reaction of pyrazolopyrimidinone based alkyne with azides using Cu(II) catalyst in presence of sodium ascorbate and evaluated for… read more here.
Keywords: ones tethered; pyrazolo pyrimidin; pyrimidin ones; synthesis pyrazolo ... See more keywords
Synthesis of arylidene hydrazinylpyrido[2,3-d]pyrimidin-4-ones as potent anti-microbial agents
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e04956
Abstract: Combination of arylidene hydrazinyl moiety with pyrido[2,3-d]pyrimidin-4-one skeleton in compounds 7‒26 results in the output of unprecedented anti-microbial agents. Arylidene hydrazinyl based on Pyrido[2,3-d]pyrimidin-4-one analoges 7‒26 prepared by the treatment of [2,3-d]pyrimidin-4-ones 6a,b with various… read more here.
Keywords: pyrimidin; pyrimidin ones; anti microbial; pyrimidin one ... See more keywords
Oxidation of thiazolo[3,2-a]pyrimidin-3(2H)-ones with DMSO and Lawesson’s reagent
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2018.02.014
Abstract: Abstract 2,2′-Dimers with a central double bond were prepared by the oxidation of 5,6-disubstituted 7-methyl-5 H -[1,3]thiazolo[3,2- a ]pyrimidin-3(2 H )-ones with DMSO and Lawesson’s reagent at room temperature. The role of DMSO as an… read more here.
Keywords: ones dmso; thiazolo pyrimidin; lawesson reagent; pyrimidin ones ... See more keywords
The ruthenium-catalyzed C-H functionalization of enamides with isocyanates: easy entry to pyrimidin-4-ones.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc03612a
Abstract: Ruthenium-catalyzed heteroannulation between enamides and isocyanates has been realized as a complementary approach to conventional strategies for the synthesis of pyrimidin-4-ones. High step- and atom-economy was achieved for the rapid construction of such privileged scaffolds,… read more here.
Keywords: functionalization enamides; pyrimidin ones; isocyanates easy; catalyzed functionalization ... See more keywords
Three-component microwave-assisted synthesis of 3,5-disubstituted pyrazolo[3,4-d]pyrimidin-4-ones
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra00980c
Abstract: A practical three-component method for the synthesis of pyrazolo[3,4-d]pyrimidin-4-ones was developed. The reaction was performed in a one-pot manner under controlled microwave irradiation using easily accessible methyl 5-aminopyrazole-4-carboxylates, trimethyl orthoformate, and primary amines. Under the… read more here.
Keywords: pyrazolo pyrimidin; three component; synthesis; pyrimidin ones ... See more keywords
Convenient One-Pot Four-Component Synthesis of 6,8-Disubstituted-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4(3H)-ones via a Triple Mannich Reaction
Sign Up to like & getrecommendations! Published in 2019 at "Australian Journal of Chemistry"
DOI: 10.1071/ch19088
Abstract: An efficient and simple one-pot four-component protocol has been developed and performed for the synthesis of 6,8-disubstituted-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4(3H)-ones, involving a triple Mannich reaction of 6-amino-2-(ethylthio)pyrimidin-4(3H)-one, formaldehyde, primary amines, and alcohols. Secondary amines were also utilised instead… read more here.
Keywords: tetrahydropyrimido pyrimidin; triple mannich; reaction; one pot ... See more keywords
Electro-Oxidative C3-Selenylation of Pyrido[1,2-a]pyrimidin-4-ones
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28052206
Abstract: In this work, we achieved a C3-selenylation of pyrido[1,2-a]pyrimidin-4-ones using an electrochemically driven external oxidant-free strategy. Various structurally diverse seleno-substituted N-heterocycles were obtained in moderate to excellent yields. Through radical trapping experiments, GC-MS analysis and… read more here.
Keywords: selenylation; selenylation pyrido; pyrido pyrimidin; pyrimidin ones ... See more keywords
Expanding the Diversity at the C-4 Position of Pyrido[2,3-d]pyrimidin-7(8H)-ones to Achieve Biological Activity against ZAP-70
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceuticals"
DOI: 10.3390/ph14121311
Abstract: Pyrido[2,3-d]pyrimidin-7(8H)-ones have attracted widespread interest due to their similarity with nitrogenous bases found in DNA and RNA and their potential applicability as tyrosine kinase inhibitors. Such structures, presenting up to five diversity centers, have allowed… read more here.
Keywords: biological activity; pyrido pyrimidin; pyrimidin; diversity position ... See more keywords