The potential of employing substituted bis[3-hydroxy-2-(pyrimidin-2-yl)-2Н-pyrazol-4-yl]methane for the synthesis of symmetrical N,O-macroheterocycles with a dioxacycloalkane central fragment
Sign Up to like & getrecommendations! Published in 2018 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-019-02409-5
Abstract: O-cyclialkylation of substituted bis[3-hydroxy-2-(pyrimidin-2-yl)-2H-pyrazol-4-yl]methane by α,ω-dibromoalkanes with a hydrocarbon chain length of up to three CH2 groups has been carried out. A novel pyrazolophane, 1,6-dioxacycloundecane with symmetrically annulated fragments of 1-(pyrimidin-2-yl)-1H-pyrazole, was isolated and characterized… read more here.
Keywords: pyrazol; pyrimidin pyrazol; substituted bis; hydroxy pyrimidin ... See more keywords
Identification, Synthesis, and Characterization of Novel Baricitinib Impurities
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DOI: 10.1021/acsomega.3c00100
Abstract: Baricitinib is a novel active pharmaceutical ingredient used in the treatment of rheumatoid arthritis, and it acts as an inhibitor of Janus kinase. During the synthesis of baricitinib, three unknown impurities were identified in several… read more here.
Keywords: characterization novel; baricitinib; synthesis characterization; synthesis ... See more keywords