Pyrazolo[3,4‐d]pyrimidine scaffold: A review on synthetic approaches and EGFR and VEGFR inhibitory activities
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200424
Abstract: The pyrazolo[3,4‐d]pyrimidine core has received a lot of interest from the medicinal chemistry community as a promising framework for drug design and discovery. It is an isostere of the adenine ring of adenosine triphosphate, which… read more here.
Keywords: scaffold review; pyrimidine scaffold; pyrazolo pyrimidine; review synthetic ... See more keywords
The Peculiar Case of the Hyper‐thermostable Pyrimidine Nucleoside Phosphorylase from Thermus thermophilus **
Sign Up to like & getrecommendations! Published in 2020 at "Chembiochem"
DOI: 10.1002/cbic.202000679
Abstract: The poor solubility of many nucleosides and nucleobases in aqueous solution demands harsh reaction conditions (base, heat, cosolvent) in nucleoside phosphorylase‐catalyzed processes to facilitate substrate loading beyond the low millimolar range. This, in turn, requires… read more here.
Keywords: pyrimidine; thermus thermophilus; pyrimidine nucleoside; phosphorylase thermus ... See more keywords
Potent Pyrimidine and Pyrrolopyrimidine Inhibitors of Testis‐Specific Serine/Threonine Kinase 2 (TSSK2)
Sign Up to like & getrecommendations! Published in 2017 at "ChemMedChem"
DOI: 10.1002/cmdc.201700503
Abstract: Testis‐specific serine/threonine kinase 2 (TSSK2) is an important target for reversible male contraception. A high‐throughput screen of ≈17 000 compounds using a mobility shift assay identified two potent series of inhibitors having a pyrrolopyrimidine or pyrimidine core.… read more here.
Keywords: specific serine; serine threonine; kinase; pyrimidine ... See more keywords
5-Amino-7-Oxo-4,7-Dihydroazolo[1,5-a]pyrimidine-6-Carbonitriles: Synthesis and Study of Antitumor Effect In Vitro and In Silico.
Sign Up to like & getrecommendations! Published in 2025 at "ChemMedChem"
DOI: 10.1002/cmdc.202500535
Abstract: A novel chemotype of nitrile‐containing azolopyrimidines with potential antitumor activity has been proposed, and a method for the synthesis of the corresponding 5‐amino‐7‐oxoazolo[1,5‐a]pyrimidine‐6‐carbonitriles by cyclocondensation of various aminoazoles and ethyl 2‐cyano‐3‐R‐amino‐3‐(methylsulfanyl)acrylates has been developed. Cytotoxic… read more here.
Keywords: pyrimidine carbonitriles; antitumor; synthesis; pyrimidine ... See more keywords
Pyrimidine-functionalized covalent organic framework and its cobalt complex as an efficient electrocatalyst for oxygen evolution reaction.
Sign Up to like & getrecommendations! Published in 2021 at "ChemSusChem"
DOI: 10.1002/cssc.202101434
Abstract: A pyrimidine-modified covalent organic framework (COF-Pyr) was designed to be synthesized via the Povarov reaction. The nitrogen atom on the pyrimidine showed excellent coordination ability to metal ions. Their stable metal composite material (Co@COF-Pyr) exhibited… read more here.
Keywords: cof pyr; covalent organic; organic framework; pyrimidine ... See more keywords
Green Synthesis and Unexpected Transformation of New Oxothiazolo[3,2‐c]Pyrimidine Carbonitriles
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.70000
Abstract: A swift microwave‐assisted Mannich cyclization between enaminocarbonitriles, formaldehyde, and primary amines giving 3‐oxothiazolo[3,2‐c]pyrimidine carbonitriles in excellent yields is reported. This protocol has some advantages such as atom‐economy, highly practical, water‐assisted, catalyst‐ and chromatography‐free. Interestingly, some… read more here.
Keywords: pyrimidine carbonitriles; synthesis unexpected; unexpected transformation; oxothiazolo pyrimidine ... See more keywords
Observation of untoward 3Jcc correlations in 1,1‐ADEQUATE spectra of pyrimidine analogs: Avoiding potential interpretation pitfalls
Sign Up to like & getrecommendations! Published in 2018 at "Magnetic Resonance in Chemistry"
DOI: 10.1002/mrc.4736
Abstract: Recently, it has been reported that large nJCC correlations can sometimes be observed in 1,1‐ADEQUATE spectra with significant intensity, which opens the possibility of structural misassignment. In this work, we have focused on pyrimidine‐based compounds,… read more here.
Keywords: adequate spectra; correlations adequate; observation untoward; pyrimidine ... See more keywords
Synthesis and purification of biotinylated oligodeoxynucleotides containing single TpT dimeric pyrimidine (6-4) pyrimidone lesion
Sign Up to like & getrecommendations! Published in 2019 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-018-01572-6
Abstract: AbstractUltraviolet (UV) radiation could induce pyrimidine-related dimeric lesions in genomic DNA. Though the cyclobutane pyrimidine dimers (CPDs) are the most abundant UV-induced lesions, the pyrimidine (6-4) pyrimidone photoproducts (6-4PPs) may have more serious, potentially lethal,… read more here.
Keywords: synthesis purification; pyrimidine pyrimidone; 4pp containing; pyrimidine ... See more keywords
Thermal, spectroscopic, X-ray and theoretical studies of metal complexes (sodium, manganese, copper, nickel, cobalt and zinc) with pyrimidine-5-carboxylic and pyrimidine-2-carboxylic acids
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Thermal Analysis and Calorimetry"
DOI: 10.1007/s10973-019-08594-x
Abstract: The new 3d metal complexes of pyrimidine-2-carboxylic (2PCA) and pyrimidine-5-carboxylic (5PCA) acids were synthesized and characterized using thermal analysis (TG–DSC, TG–FTIR), X-ray, spectroscopic (IR, Raman) methods and theoretical (DFT) studies. In the complexes of pyrimidine-2-carboxylic… read more here.
Keywords: pyrimidine; spectroscopic; metal complexes; pyrimidine carboxylic ... See more keywords
An efficient one-pot synthesis of highly functionalized benzylpyrazolyl pyrido[1,2-a]pyrimidine derivatives using CuFe2O4 nanoparticles under solvent-free conditions
Sign Up to like & getrecommendations! Published in 2017 at "Research on Chemical Intermediates"
DOI: 10.1007/s11164-017-3022-4
Abstract: An efficient and green protocol for the synthesis of novel benzylpyrazolyl pyrido[1,2-a]pyrimidine derivatives via three-component reaction of aryl aldehydes, 2-hydroxy-4H-pyrido[1,2-a]pyrimidine-4-ones, and 3-methyl-1-phenyl-1H-pyrazol-5-one has been reported using a magnetically separable and reusable heterogeneous copper ferrite (CuFe2O4)… read more here.
Keywords: free conditions; benzylpyrazolyl pyrido; pyrimidine derivatives; pyrimidine ... See more keywords
Synthesis of androsteno[17,16-d]pyrazoles and androsteno[17,16-d]-2′-pyrazolines with pyrazolo[3,4-d]pyrimidine fragments
Sign Up to like & getrecommendations! Published in 2018 at "Russian Chemical Bulletin"
DOI: 10.1007/s11172-018-2185-5
Abstract: Reactions of pyrazolo[3,4-d]pyrimidine-containing hydrazines with pregnenolone derivatives were studied. The reaction of 16α,17α-epoxy-3β-hydroxy-5-pregnen-20-one and its 3-O-acetyl derivative with 6-hydrazino-3,4-dimethyl-1H-pyrazolo[3,4-d]pyrimidine and 4-hydrazino-3-methyl-6-phenyl-1H-pyrazolo[3,4-d]pyrimidine afforded new androsteno[17,16-d]pyrazoles with pyrazolo[3,4-d]pyrimidine fragments. The reaction of 3β-hydroxypregna-5,16-dien-20-one and its 3-O-acetyl derivative… read more here.
Keywords: pyrimidine; pyrimidine fragments; pyrazolo pyrimidine; androsteno pyrazoles ... See more keywords