Novel Pyrido[4,3‑d]pyrimidine Compounds as KRAS Inhibitors.
Sign Up to like & getrecommendations! Published in 2025 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.5c00493
Abstract: This highlight describes novel substituted pyrido-[4,3-d]-pyrimidine compounds as KRAS (Kirsten rat sarcoma viral oncogene homologue) inhibitors. The invention provides details about novel pyrido-[4,3-d]-pyrimidine compounds, their pharmaceutical composition, potential use, and treatment for KRAS-related diseases, such… read more here.
Keywords: novel pyrido; compounds kras; kras inhibitors; pyrido pyrimidine ... See more keywords
Imidazo Pyrimidine Compounds for the Inhibition of Oncogenic KRAS Mutations in Cancer Therapy.
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DOI: 10.1021/acsmedchemlett.5c00628
Abstract: This highlight outlines the development of novel imidazo-pyrimidine compounds as potent inhibitors targeting oncogenic KRAS mutations, including G12D, G12V, and G12C. The disclosure includes details on synthetic methods, biological evaluation, metabolic stability, and pharmaceutical compositions. read more here.
Keywords: oncogenic kras; inhibition oncogenic; pyrimidine compounds; imidazo pyrimidine ... See more keywords
Synthesis, Characterization, Antimicrobial Activity, and Molecular Docking Study of Newer Chalcone-based Triazolo Pyrimidine Compounds
Sign Up to like & getrecommendations! Published in 2024 at "Current Organic Chemistry"
DOI: 10.2174/0113852728298472240305110906
Abstract: In this work, we present the synthesis of a newer series of 15 chalcone-based pyrimidine compounds 4a-o. All the compounds were characterized by elemental analysis, melting point determination, mass, FTIR, and NMR analysis. We have… read more here.
Keywords: molecular docking; chalcone based; pyrimidine compounds; docking study ... See more keywords