QSAR and Molecular Docking Studies of Pyrimidine-Coumarin-Triazole Conjugates as Prospective Anti-Breast Cancer Agents
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DOI: 10.3390/molecules27061845
Abstract: Cancer is a life-threatening disease and is the second leading cause of death worldwide. Although many drugs are available for the treatment of cancer, survival outcomes are very low. Hence, rapid development of newer anticancer… read more here.
Keywords: pyrimidine coumarin; breast cancer; triazole conjugates; coumarin triazole ... See more keywords
Discovery of Pyrimidine- and Coumarin-Linked Hybrid Molecules as Inducers of JNK Phosphorylation through ROS Generation in Breast Cancer Cells
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DOI: 10.3390/molecules28083450
Abstract: Human epidermal growth factor receptor 2 (HER2)-positive breast cancer exhibits early relapses, poor prognoses, and high recurrence rates. Herein, a JNK-targeting compound has been developed that may be of utility in HER2-positive mammary carcinoma. The… read more here.
Keywords: phosphorylation ros; coumarin linked; jnk phosphorylation; breast cancer ... See more keywords