A novel thieno[2,3-d]pyrimidine derivative inhibiting vascular endothelial growth factor receptor-2: A story of computer-aided drug discovery.
Sign Up to like & getrecommendations! Published in 2023 at "Drug development research"
DOI: 10.1002/ddr.22083
Abstract: Following the pharmacophoric features of vascular endothelial growth factor receptor 2 (VEGFR-2) inhibitors, a novel thieno[2,3-d]pyrimidine derivative has been designed and its activity against VEGFR-2 has been demonstrated by molecular docking studies that showed an… read more here.
Keywords: pyrimidine derivative; growth; thieno pyrimidine; drug ... See more keywords
Inhibition effect of a new pyrimidine derivative on the corrosion of mild steel in hydrochloric acid solution
Sign Up to like & getrecommendations! Published in 2017 at "Surface Engineering and Applied Electrochemistry"
DOI: 10.3103/s1068375517010112
Abstract: The inhibition effect of a newly synthesized pyrimidine derivative, namely 3-(2-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)ethyl)-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one, on the corrosion of mild steel in 1.0 M HCl medium was investigated using the weight loss, the Tafel extrapolation technique and the AC… read more here.
Keywords: mild steel; pyrimidine derivative; corrosion; effect ... See more keywords
The Pyrazolo[3,4-d]Pyrimidine Derivative Si306 Encapsulated into Anti-GD2-Immunoliposomes as Therapeutic Treatment of Neuroblastoma
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10030659
Abstract: Si306, a pyrazolo[3,4-d]pyrimidine derivative recently identified as promising anticancer agent, has shown favorable in vitro and in vivo activity profile against neuroblastoma (NB) models by acting as a competitive inhibitor of c-Src tyrosine kinase. Nevertheless,… read more here.
Keywords: gd2; si306 encapsulated; pyrimidine derivative; neuroblastoma ... See more keywords
The Administration of the New Pyrimidine Derivative—4-{2-[2-(3,4-Dimethoxyphenyl)-Vinyl]-6-Ethyl-4-Oxo-5-Phenyl-4H-Pyrimidine-1-Il}Benzsulfamide Restores the Activity of Brain Cells in Experimental Chronic Traumatic Encephalopathy by Maintaining Mitochondrial Function
Sign Up to like & getrecommendations! Published in 2019 at "Medicina"
DOI: 10.3390/medicina55070386
Abstract: Background and objectives: To evaluate the effect of a new pyrimidine derivative on the change of mitochondrial function in experimental chronic traumatic encephalopathy. Materials and methods: The study was performed on male mice of the… read more here.
Keywords: traumatic encephalopathy; pyrimidine derivative; function; chronic traumatic ... See more keywords