Utility of 5-(2',4'-dimethylphenylazo)-6-hydroxy-pyrimidine-2,4-dione in PVC membrane for a novel green optical chemical sensor to detect zinc ion in environmental samples.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2022.114579
Abstract: In plasticized (2-nitro-phenyloctyl ether (o-NPOE)) and polyvinyl chloride (PVC) membrane incorporating (N,N-diethyl-5-(octadecanoylimino)-5H-benzo[a] phenolxazine-9-amine (ETH 5294) and sodium tetraphenyl borate (NaTPB), an ionophore 5-(2',4'-dimethylphenylazo)-6-hydroxy-pyrimidine-2,4-dione (DMPAHPD) form an optical chemical sensor for zinc determination is ascribed. The… read more here.
Keywords: hydroxy pyrimidine; membrane; pyrimidine dione; sensor ... See more keywords
Novel pyrimidine-2,4-dione-1,2,3-triazole and furo[2,3-d]pyrimidine-2-one-1,2,3-triazole hybrids as potential anti-cancer agents: Synthesis, computational and X-ray analysis and biological evaluation.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.11.028
Abstract: Regioselective 1,4-disubstituted 1,2,3-triazole tethered pyrimidine-2,4-dione derivatives (5-23) were successfully prepared by the copper(I)-catalyzed click chemistry. While known palladium/copper-cocatalyzed method based on Sonogashira cross-coupling followed by the intramolecular 5-endo-dig ring closure generated novel 6-alkylfuro[2,3-d]pyrimidine-2-one-1,2,3-triazole hybrids (24b-37b),… read more here.
Keywords: triazole; pyrimidine one; chemistry; pyrimidine ... See more keywords
Discovery of a Potent Thieno[2,3-d]pyrimidine-2,4-dione-Based Protoporphyrinogen IX Oxidase Inhibitor through an In Silico Structure-Guided Optimization Approach.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c05665
Abstract: A key objective for herbicide research is to develop new compounds with improved bioactivity. Protoporphyrinogen IX oxidase (PPO) is an essential target for herbicide discovery. Here, we report using an in silico structure-guided optimization approach… read more here.
Keywords: thieno pyrimidine; pyrimidine dione; structure guided; guided optimization ... See more keywords
Synthesis and Herbicidal Activity of Pyrido[2,3-d]pyrimidine-2,4-dione-Benzoxazinone Hybrids as Protoporphyrinogen Oxidase Inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.7b01990
Abstract: To search for new protoporphyrinogen oxidase (PPO, EC 1.3.3.4) inhibitors with improved bioactivity, a series of novel pyrido[2,3-d]pyrimidine-2,4-dione-benzoxazinone hybrids, 9-13, were designed and synthesized. Several compounds with improved tobacco PPO (mtPPO)-inhibiting and promising herbicidal activities… read more here.
Keywords: dione; protoporphyrinogen oxidase; dione benzoxazinone; pyrimidine dione ... See more keywords
Novel Quinolinyl-pyrrolo[3,4-d]pyrimidine-2,5-dione Derivatives Against Chloroquine-resistant Plasmodium falciparum.
Sign Up to like & getrecommendations! Published in 2019 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026619666191019100711
Abstract: AIMS Obtaining new quinolinyl-pyrrolopyrimidinone derivatives against chloroquine-resistant Plasmodium falciparum. Background: Malaria is currently considered one of the most serious public health problems, with an estimated 219 million new cases in 2017. The number of drugs… read more here.
Keywords: quinolinyl; pyrrolo pyrimidine; pyrimidine dione; quinolinyl pyrrolo ... See more keywords