Iodine-Catalyzed Multicomponent Synthesis of Highly Fluorescent Pyrimidine-Linked Imidazopyridines
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DOI: 10.1021/acsomega.2c01332
Abstract: Herein, we report a metal-free one-pot three-component reaction of aryl methyl ketones, 2-aminopyridines, and barbituric acids for the synthesis of pyrimidine-linked imidazopyridines using a catalytic amount of molecular iodine in DMSO medium. This process involves… read more here.
Keywords: pyrimidine linked; fluorescence quantum; linked imidazopyridines; synthesis ... See more keywords
Novel pyrimidine linked acyl thiourea derivatives as potent α-amylase and proteinase K inhibitors: design, synthesis, molecular docking and ADME studies
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DOI: 10.1039/d4ra05799f
Abstract: To discover promising therapeutic agents, novel diaryl pyrimidine linked acyl thiourea derivatives (6a–j) were designed and synthesized via straightforward and multistep synthesis. The structure of these derivatives (6a–j) was confirmed by FTIR, 1H, and 13C… read more here.
Keywords: amylase proteinase; pyrimidine linked; linked acyl; pyrimidine ... See more keywords