De novo pyrimidine synthesis is necessary for intestinal colonization of Salmonella Typhimurium in chicks
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0183751
Abstract: pyrE (STM3733) encodes orotate phosphoribosyltransferase (OPRTase; EC 2.4.2.10), the fifth enzyme of the de novo pyrimidine biosynthetic pathway. We identified a ΔpyrE mutant as under selection in screening of a Salmonella mutant library in 4-day… read more here.
Keywords: synthesis necessary; pyre mutant; salmonella; colonization ... See more keywords
Targeting the Leukemic stem cell protein machinery by inhibition of mitochondrial pyrimidine synthesis
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202216171
Abstract: Acute Myeloid Leukemia is one of the most aggressive blood cancers with a high frequency of relapse. While standard chemotherapy is able to target rapidly proliferating immature blasts, it fails to eradicate slowly proliferating Leukemic… read more here.
Keywords: leukemic stem; medicine; pyrimidine synthesis;
Key Enzymes in Pyrimidine Synthesis, CAD and CPS1, Predict Prognosis in Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13040744
Abstract: Simple Summary Individual patients with liver cancer have a highly variable clinical course. Hence, there is an urgent need to identify new prognostic markers to determine prognosis and select specific therapies. Expression of two key… read more here.
Keywords: key enzymes; prognosis; cad; pyrimidine synthesis ... See more keywords