New pyrimidine/thiazole hybrids endowed with analgesic, anti-inflammatory, and lower cardiotoxic activities: Design, synthesis, and COX-2/sEH dual inhibition.
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DOI: 10.1002/ardp.202200024
Abstract: Some cyclooxygenase (COX)-2 selective medications were withdrawn from the market just a few years after their production due to cardiovascular side effects. In this study, a new series of pyrimidine/thiazole hybrids 7a-p was synthesized as… read more here.
Keywords: pyrimidine thiazole; cox; analgesic anti; anti inflammatory ... See more keywords