Exploration of Pyrido[3,4-d]pyrimidines as Antagonists of the Human Chemokine Receptor CXCR2
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DOI: 10.3390/molecules28052099
Abstract: Upregulated CXCR2 signalling is found in numerous inflammatory, autoimmune and neurodegenerative diseases, as well as in cancer. Consequently, CXCR2 antagonism is a promising therapeutic strategy for treatment of these disorders. We previously identified, via scaffold… read more here.
Keywords: exploration pyrido; pyrimidines antagonists; pyrido; cxcr2 ... See more keywords