Design, synthesis and bioevaluation of 2,7-diaryl-pyrazolo[1,5-a]pyrimidines as tubulin polymerization inhibitors.
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DOI: 10.1016/j.bioorg.2021.105220
Abstract: Two series of 2,7-diaryl-pyrazolo[1,5-a]pyrimidines as tubulin polymerization inhibitors were designed to restrict bioactive configuration of (E,Z)-vinylogous CA-4. All of the target compounds were synthesized and then evaluated for their in vitro antiproliferative activities against three… read more here.
Keywords: polymerization; polymerization inhibitors; pyrazolo pyrimidines; diaryl pyrazolo ... See more keywords