Synthesis and biological evaluation of pyrimidinyl sulphonamide derivatives as promising class of antitubercular agents
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DOI: 10.1016/j.jscs.2015.05.007
Abstract: Abstract A small library of compounds are synthesized and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37RV. Two compounds, -[(2′,4′-dinitrophenyl)sulphonyl]-4-(p-aminophenylsulphonylamino)-6-(2′-chlorophenyl)-pyrimidine-5-carboxamide F b and 2-hydrazino-4-(p-aminophenylsulphonylamino)-6-(2′-chlorophenyl)-pyrimidine-5-carboxamide D b were found to be the most… read more here.
Keywords: sulphonamide derivatives; biological evaluation; pyrimidinyl sulphonamide; evaluation pyrimidinyl ... See more keywords