Design, synthesis and anti leukemia cells proliferation activities of pyrimidylaminoquinoline derivatives as DOT1L inhibitors.
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DOI: 10.1016/j.bioorg.2018.07.022
Abstract: A series of novel pyrimidylaminoquinoline derivatives 8(a-i) and 9(a-i) containing amino side chain, and the bisaminoquinoline analogs 3(b-e) have been designed and synthesized by structural modifications on a lead DOT1L inhibitor, 3a. All the compounds… read more here.
Keywords: leukemia cells; proliferation activities; pyrimidylaminoquinoline derivatives; cells proliferation ... See more keywords