Function and mechanism of the pyrin inflammasome
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DOI: 10.1002/eji.201746947
Abstract: Pyrin, encoded by the MEFV gene, is an intracellular pattern recognition receptor that assembles inflammasome complexes in response to pathogen infections. Mutations in the MEFV gene have been linked to autoinflammatory diseases such as familial… read more here.
Keywords: pyrin inflammasome; mechanism pyrin; function mechanism; immunology ... See more keywords
The Pyrin Inflammasome in Health and Disease
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01745
Abstract: The pyrin inflammasome has evolved as an innate immune sensor to detect bacterial toxin-induced Rho guanosine triphosphatase (Rho GTPase)-inactivation, a process that is similar to the “guard” mechanism in plants. Rho GTPases act as molecular… read more here.
Keywords: pyrin inflammasome; activity; inflammasome health; disease ... See more keywords