Construction of a sensitive pyrogen‐testing cell model by site‐specific knock‐in of multiple genes
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27084
Abstract: A pyrogen test is crucial for evaluating the safety of drugs and medical equipment, especially those involved in injections. As existing pyrogen tests, including the rabbit pyrogen test, the limulus amoebocyte lysate (LAL) test and… read more here.
Keywords: pyrogen; knock; cell model; test ... See more keywords
A novel alternative for pyrogen detection based on a transgenic cell line
Sign Up to like & getrecommendations! Published in 2024 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-024-01744-0
Abstract: Pyrogen, often as a contaminant, is a key indicator affecting the safety of almost all parenteral drugs (including biologicals, chemicals, traditional Chinese medicines and medical devices). It has become a goal to completely replace the… read more here.
Keywords: alternative pyrogen; test; pyrogen detection; pyrogen ... See more keywords
Development of a Monocyte Activation Test for Evaluating Recombinant Hepatitis B Vaccine: A Novel Approach for Pyrogen Assessment
Sign Up to like & getrecommendations! Published in 2024 at "Iranian Biomedical Journal"
DOI: 10.61186/ibj.4100
Abstract: Background: Injectable products, particularly human vaccines, must be free from fever-inducing agents and thoroughly tested for pyrogens as part of a quality control. Consequently, manufacturing facilities are required to conduct appropriate pyrogen tests per pharmacopoeial… read more here.
Keywords: recombinant hepatitis; hepatitis vaccine; development monocyte; vaccine ... See more keywords