Widening the options for recurrent malaria
Sign Up to like & getrecommendations! Published in 2018 at "The Lancet"
DOI: 10.1016/s0140-6736(18)30630-5
Abstract: The global need for new antimalarial drugs and new combinations is enormous and urgent, but their successful delivery needs resilience to overcome the barriers imposed by expensive and lengthy clinical development plans. Attention is often… read more here.
Keywords: artesunate dihydroartemisinin; recurrent malaria; pyronaridine artesunate; artesunate ... See more keywords
Efficacy and Safety of Pyronaridine-Artesunate plus Single-Dose Primaquine for the Treatment of Malaria in Western Cambodia
Sign Up to like & getrecommendations! Published in 2019 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01273-19
Abstract: This single-arm trial (n = 104) in western Cambodia showed high efficacy for 3-day treatment with pyronaridine-artesunate plus single-dose primaquine in Plasmodium falciparum malaria. ABSTRACT This single-arm trial (n = 104) in western Cambodia showed high efficacy for 3-day… read more here.
Keywords: western cambodia; pyronaridine artesunate; single dose; plus single ... See more keywords
Hepatic safety of repeated treatment with pyronaridine‐artesunate versus artemether–lumefantrine in patients with uncomplicated malaria: a secondary analysis of the WANECAM 1 data from Bobo-Dioulasso, Burkina Faso
Sign Up to like & getrecommendations! Published in 2021 at "Malaria Journal"
DOI: 10.1186/s12936-021-03593-6
Abstract: Background The use of pyronaridine-artesunate (PA) has been associated with scarce transaminitis in patients. This analysis aimed to evaluate the hepatic safety profile of repeated treatment with PA versus artemether–lumefantrine (AL) in patients with consecutive… read more here.
Keywords: artemether lumefantrine; pyronaridine artesunate; hepatic safety; uncomplicated malaria ... See more keywords
Inter-Species Pharmacokinetic Modeling and Scaling for Drug Repurposing of Pyronaridine and Artesunate
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DOI: 10.3390/ijms25136998
Abstract: Even though several new targets (mostly viral infection) for drug repurposing of pyronaridine and artesunate have recently emerged in vitro and in vivo, inter-species pharmacokinetic (PK) data that can extend nonclinical efficacy to humans has… read more here.
Keywords: drug repurposing; pyronaridine artesunate; inter species;
Application of Minimal Physiologically-Based Pharmacokinetic Model to Simulate Lung and Trachea Exposure of Pyronaridine and Artesunate in Hamsters
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15030838
Abstract: A fixed-dose combination of pyronaridine and artesunate, one of the artemisinin-based combination therapies, has been used as a potent antimalarial treatment regimen. Recently, several studies have reported the antiviral effects of both drugs against severe… read more here.
Keywords: pyronaridine artesunate; artesunate; lung trachea;