Synthesis of 4-Pyrones by Formal Hydration of 1,3-Diynones Promoted by 1,4-Addition of Piperidine.
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DOI: 10.1021/acs.orglett.2c02914
Abstract: A new approach for the synthesis of 4-pyrones with broader substrate scope and functional group tolerance is described. The reaction proceeds via an initial 1,4-addition by piperidine, followed by nitrogen-assisted 6-endo-dig cyclization and hydrolysis. 1,3-Diynones… read more here.
Keywords: synthesis pyrones; addition piperidine; pyrones formal; formal hydration ... See more keywords