Implantable Bioresponsive Nanoarray Enhances Postsurgical Immunotherapy by Activating Pyroptosis and Remodeling Tumor Microenvironment
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DOI: 10.1002/adfm.202005747
Abstract: Despite the potential of drug‐loaded scaffolds for tumor recurrence and metastasis (TRM) postoperation, their therapeutic benefits are limited by marked immunosuppressive tumor microenvironment (ITME) and drug‐related untargeted toxicity. Herein, an innovative implantable bioresponsive nanoarray is… read more here.
Keywords: tumor; tumor microenvironment; pyroptosis; nanoarray ... See more keywords
Diselenide‐Based Dual‐Responsive Prodrug as Pyroptosis Inducer Potentiates Cancer Immunotherapy
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DOI: 10.1002/adhm.202202135
Abstract: Pyroptosis is demonstrated to trigger antitumor immunity and represents a promising new strategy to potentiate cancer immunotherapy. The number of potent pyroptosis inducers, however, is limited and without tumor‐targeting capability, which inevitably causes damage in… read more here.
Keywords: dual responsive; pyroptosis; dse poc; cancer immunotherapy ... See more keywords
Prussian Blue Nanozyme as a Pyroptosis Inhibitor Alleviates Neurodegeneration
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DOI: 10.1002/adma.202106723
Abstract: Current pharmacological interventions for Parkinson's disease (PD) remain unsatisfactory in clinical settings. Inflammasome‐mediated pyroptosis represents a potential therapeutic target for the alleviation of neurodegenerative diseases. The development of inflammasome‐mediated pyroptosis agonists or antagonists may transform… read more here.
Keywords: pyroptosis inhibitor; blue nanozyme; pyroptosis; nanozyme pyroptosis ... See more keywords
A Dual‐Locked Tandem Fluorescent Probe for Imaging of Pyroptosis in Cancer Chemo‐Immunotherapy
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DOI: 10.1002/adma.202206510
Abstract: Real‐time imaging of programmed cancer cell death (PCD) is imperative to monitor cancer therapeutic efficacy and tailor therapeutic regimens; however, specific in vivo detection of intratumoral pyroptosis remains challenging. Herein, a dual‐locked and tandem activatable… read more here.
Keywords: pyroptosis cancer; pyroptosis; cancer chemo; cancer ... See more keywords
Ultrasound‐Amplified Enzyodynamic Tumor Therapy by Perovskite Nanoenzyme‐Enabled Cell Pyroptosis and Cascade Catalysis
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DOI: 10.1002/adma.202208817
Abstract: Overcoming apoptosis resistance to achieve efficient breast cancer treatment remains a challenge. The precise induction of another form of programmed cell death, pyroptosis, is an excellent alternative for treating cancer. Ultrasound (US)‐enhanced enzyme dynamic (enzyodynamic)… read more here.
Keywords: cell; pyroptosis; therapy; ultrasound amplified ... See more keywords
A Dual‐Responsive STAT3 Inhibitor Nanoprodrug Combined with Oncolytic Virus Elicits Synergistic Antitumor Immune Responses by Igniting Pyroptosis
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DOI: 10.1002/adma.202209379
Abstract: Immune checkpoint blockade (ICB) therapy shows excellent efficacy against malignancies; however, insufficient tumor immunogenicity and the immunosuppressive tumor microenvironment (TME) are considered as the two major stumbling blocks to a broad ICB response. Here, a… read more here.
Keywords: antitumor immune; pyroptosis; combined oncolytic; dual responsive ... See more keywords
Stepwise Size Shrinkage Cascade‐Activated Supramolecular Prodrug Boosts Antitumor Immunity by Eliciting Pyroptosis
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DOI: 10.1002/advs.202203353
Abstract: Effective pyroptosis induction is a promising approach to potentiate cancer immunotherapy. However, the actual efficacy of the present pyroptosis inducers can be weakened by successive biological barriers. Here, a cascaded pH‐activated supramolecular nanoprodrug (PDNP) with… read more here.
Keywords: pyroptosis; size shrinkage; activated supramolecular; size ... See more keywords
Nanomedicine‐Enabled/Augmented Cell Pyroptosis for Efficient Tumor Nanotherapy
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DOI: 10.1002/advs.202203583
Abstract: The terrible morbidity and mortality of malignant tumors urgently require innovative therapeutics, especially for apoptosis‐resistant tumors. Pyroptosis, a pro‐inflammatory form of programmed cell death (PCD), is featured with pore formation in plasma membrane, cell swelling… read more here.
Keywords: cell; pyroptosis; enabled augmented; nanomedicine enabled ... See more keywords
Neutrophil Camouflaged Stealth Nanovehicle for Photothermal‐Induced Tumor Immunotherapy by Triggering Pyroptosis
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DOI: 10.1002/advs.202207456
Abstract: The regulation of tumor immunosuppressive microenvironments via precise drug delivery is a promising strategy for preventing tumor recurrence and metastasis. Inspired by the stealth strategy, a stealthy nanovehicle based on neutrophil camouflage is developed to… read more here.
Keywords: pyroptosis; nanovehicle; tumor immunotherapy; immunotherapy triggering ... See more keywords
Identification of pyroptosis‐related gene prognostic signature in head and neck squamous cell carcinoma
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DOI: 10.1002/cam4.4825
Abstract: Head and neck squamous cell carcinoma (HNSCC) is a life‐threatening disease with poor prognosis. Pyroptosis has been recently disclosed as a programmed cell death triggered by invasive infection, involved in cancer development. However, the prognosis… read more here.
Keywords: cell; cell carcinoma; head neck; pyroptosis ... See more keywords
Identification of a pyroptosis‐based model for predicting clinical outcomes from immunotherapy in patients with metastatic melanoma
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DOI: 10.1002/cam4.5178
Abstract: Immunotherapy has greatly improved outcomes for patients with advanced melanoma, but good predictive biomarkers remain lacking in clinical practice. Although increasing evidence has revealed a vital role of pyroptosis in the tumor microenvironment (TME), it… read more here.
Keywords: predicting clinical; pyroptosis; pyroptosis based; based model ... See more keywords