Implantable Bioresponsive Nanoarray Enhances Postsurgical Immunotherapy by Activating Pyroptosis and Remodeling Tumor Microenvironment
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DOI: 10.1002/adfm.202005747
Abstract: Despite the potential of drug‐loaded scaffolds for tumor recurrence and metastasis (TRM) postoperation, their therapeutic benefits are limited by marked immunosuppressive tumor microenvironment (ITME) and drug‐related untargeted toxicity. Herein, an innovative implantable bioresponsive nanoarray is… read more here.
Keywords: tumor; tumor microenvironment; pyroptosis; nanoarray ... See more keywords
Pyroptosis of Breast Cancer Stem Cells and Immune Activation Enabled by a Multifunctional Prodrug Photosensitizer
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DOI: 10.1002/adfm.202405367
Abstract: Breast cancer stem cells (CSCs) are responsible for the occurrence, resistance, recurrence, invasion, and metastasis of tumors. However, even trace amounts of CSCs may lead to tumor resistance and recurrence, which fundamentally reduces the therapeutic… read more here.
Keywords: cancer; breast cancer; breast; pyroptosis ... See more keywords
Pyroptosis‐Inducing Self‐Adaptor to Potentiate Immune Checkpoint Blockade Therapy for Breast Cancer by Reeducating the Treatment‐Recruited Macrophages
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DOI: 10.1002/adfm.202414847
Abstract: Treatment‐induced cell pyroptosis can improve the immunogenicity of breast cancer and enhance the efficacy of immune checkpoint blockade (ICB), but the resultant recruitment of immunosuppressive cells impedes the systemic anti‐tumor immunity. Herein, a rationally designed… read more here.
Keywords: breast cancer; cancer; pyroptosis; immune checkpoint ... See more keywords
Self‐Enhancing Drug Pair‐Driven Selenium Nanotherapeutics Reverses Microglial Pyroptosis Through NLRP3/Caspase‐1 Pathway and Neuronal Apoptosis for Treatment of Spinal Cord Injury
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DOI: 10.1002/adfm.202503505
Abstract: Spinal cord injury (SCI) constitutes a critical occurrence that results in the disruption of both motor and sensory functions. Oxidative stress‐induced apoptosis and pyroptosis have been identified as critical contributors to neuronal damage during the… read more here.
Keywords: pyroptosis; pair driven; drug pair; injury ... See more keywords
Diselenide‐Based Dual‐Responsive Prodrug as Pyroptosis Inducer Potentiates Cancer Immunotherapy
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DOI: 10.1002/adhm.202202135
Abstract: Pyroptosis is demonstrated to trigger antitumor immunity and represents a promising new strategy to potentiate cancer immunotherapy. The number of potent pyroptosis inducers, however, is limited and without tumor‐targeting capability, which inevitably causes damage in… read more here.
Keywords: dual responsive; pyroptosis; dse poc; cancer immunotherapy ... See more keywords
Fluoroalkane Engineered Magnetic Vectors Unlock the Potential of Gasdermin in Vivo Delivery for Pyroptosis Induced Cancer Therapy
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DOI: 10.1002/adhm.202500801
Abstract: Pyroptosis, a programmed necrotic cell death mediated by gasdermin, can activate strong immune responses and serve as a potential target for cancer therapy. Nevertheless, the relatively large molecular size and negative surface charge of gasdermin… read more here.
Keywords: delivery system; pyroptosis; gasdermin; delivery ... See more keywords
Programmed Aggregation of Lipidated Nitrobenzoselenadiazole as a Photo‐Activatable Pyroptosis Inducer
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DOI: 10.1002/adhm.202501567
Abstract: Bioactive photosensitizers in photodynamic therapy (PDT) have emerged as a promising therapeutic approach for tumor treatment. However, the aggregation of photosensitizers in aqueous solutions could hinder their efficacy, leading to reduced generation of reactive oxygen… read more here.
Keywords: programmed aggregation; photo; pyroptosis; lipidated nitrobenzoselenadiazole ... See more keywords
Prussian Blue Nanozyme as a Pyroptosis Inhibitor Alleviates Neurodegeneration
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DOI: 10.1002/adma.202106723
Abstract: Current pharmacological interventions for Parkinson's disease (PD) remain unsatisfactory in clinical settings. Inflammasome‐mediated pyroptosis represents a potential therapeutic target for the alleviation of neurodegenerative diseases. The development of inflammasome‐mediated pyroptosis agonists or antagonists may transform… read more here.
Keywords: pyroptosis inhibitor; blue nanozyme; pyroptosis; nanozyme pyroptosis ... See more keywords
A Dual‐Locked Tandem Fluorescent Probe for Imaging of Pyroptosis in Cancer Chemo‐Immunotherapy
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DOI: 10.1002/adma.202206510
Abstract: Real‐time imaging of programmed cancer cell death (PCD) is imperative to monitor cancer therapeutic efficacy and tailor therapeutic regimens; however, specific in vivo detection of intratumoral pyroptosis remains challenging. Herein, a dual‐locked and tandem activatable… read more here.
Keywords: pyroptosis cancer; pyroptosis; cancer chemo; cancer ... See more keywords
Ultrasound‐Amplified Enzyodynamic Tumor Therapy by Perovskite Nanoenzyme‐Enabled Cell Pyroptosis and Cascade Catalysis
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DOI: 10.1002/adma.202208817
Abstract: Overcoming apoptosis resistance to achieve efficient breast cancer treatment remains a challenge. The precise induction of another form of programmed cell death, pyroptosis, is an excellent alternative for treating cancer. Ultrasound (US)‐enhanced enzyme dynamic (enzyodynamic)… read more here.
Keywords: cell; pyroptosis; therapy; ultrasound amplified ... See more keywords
A Dual‐Responsive STAT3 Inhibitor Nanoprodrug Combined with Oncolytic Virus Elicits Synergistic Antitumor Immune Responses by Igniting Pyroptosis
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DOI: 10.1002/adma.202209379
Abstract: Immune checkpoint blockade (ICB) therapy shows excellent efficacy against malignancies; however, insufficient tumor immunogenicity and the immunosuppressive tumor microenvironment (TME) are considered as the two major stumbling blocks to a broad ICB response. Here, a… read more here.
Keywords: antitumor immune; pyroptosis; combined oncolytic; dual responsive ... See more keywords