Pyruvate kinase M2 (PKM2) interacts with activating transcription factor 2 (ATF2) to bridge glycolysis and pyroptosis in microglia.
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DOI: 10.1016/j.molimm.2021.10.017
Abstract: Pyruvate kinase M2 (PKM2), a glycolytic rate-limiting enzyme, reportedly plays an important role in tumorigenesis and the inflammatory response by regulating the metabolic reprogramming. However, its contribution to microglial activation during neuroinflammation is still unknown.… read more here.
Keywords: glycolysis; pyroptosis; pkm2; pyroptosis microglia ... See more keywords