Preparation of novel pyrrol-2-one derivatives via an effective synthesis of new oxazole scaffold
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DOI: 10.1016/j.tet.2017.01.046
Abstract: Abstract A convenient procedure for the preparation of oxazole and pyrrole derivatives is described. 2-Amino-1,3-oxazol-2-ones 3a,b were first synthesized from the cyclocondensation reactions of cyanamide (2) with 4-ethoxycarbonyl-5-aryl-2,3-furandione 1a,b, and then new pyrrol-2-ones 5 were… read more here.
Keywords: preparation novel; one derivatives; pyrrol; pyrrol one ... See more keywords
1,2-Dihydrochromeno[2,3-c]pyrrol-3-one Derivatives: Synthesis and HPLC-ECD Analysis
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DOI: 10.1055/s-0037-1612085
Abstract: Ethyl-3-formyl-6-methoxy-(2H)-chromene-2-carboxylate was transformed to N-substituted 1,2-dihydrochromeno[2,3-c]pyrrol-3-ones in a domino reductive amination–lactamization reaction. Isomerization of the double bond and the inherently labile stereogenic center was studied, and HPLC-ECD analysis of a chiral 1,2-dihydrochromeno[2,3-c]pyrrol-3(3aH)-one derivative aided by… read more here.
Keywords: dihydrochromeno pyrrol; hplc ecd; pyrrol; ecd analysis ... See more keywords
Solvent Free Three-Component Synthesis of 2,4,5-trisubstituted-1H-pyrrol-3-ol-type Compounds from L-tryptophan: DFT-B3LYP Calculations for the Reaction Mechanism and 3H-pyrrol-3-one↔1H-pyrrol-3-ol Tautomeric Equilibrium
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DOI: 10.3390/molecules25194402
Abstract: In this paper, we describe the solvent-free three-component synthesis of 2,4,5-trisubstituted-1H-pyrrol-3-ol-type compounds from L-tryptophan. The first step of the synthetic methodology involved the esterification of L-tryptophan in excellent yields (93–98%). Equimolar mixtures of alkyl 2-aminoesters,… read more here.
Keywords: pyrrol; pyrrol type; three component; solvent free ... See more keywords