Assembly of 3-sulfonated 2H-pyrrol-2-ones through the insertion of sulfur dioxide with allenoic amides
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2020.08.037
Abstract: Abstract Generation of 3-sulfonated 2H-pyrrol-2-ones through a three-component reaction of allenoic amides, sulfur dioxide, and aryldiazonium tetrafluoroborates under metal-free conditions is achieved. This transformation proceeds under mild conditions without the addition of catalysts or additives,… read more here.
Keywords: sulfur dioxide; sulfonated pyrrol; allenoic amides; pyrrol ones ... See more keywords
Synthesis of Chromeno[4,3-b]pyrrol-4(1H)-ones through a Multicomponent Reaction and Cyclization Strategy
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.0c03589
Abstract: A novel three-component reaction of 2-oxo-2H-chromene-3-carbaldehydes with isocyanides and anilines was developed for one-pot assembly of biologically intriguing chromeno[4,3-b]pyrrol-4(1H)-ones, which can also be transferred into diverse polycyclic fused scaffolds through further synthetic manipulations. The described… read more here.
Keywords: multicomponent reaction; cyclization; reaction; pyrrol ones ... See more keywords
Palladium-catalyzed double carbonylation of propargyl amines and aryl halides to access 1-aroyl-3-aryl-1,5-dihydro-2H-pyrrol-2-ones
Sign Up to like & getrecommendations! Published in 2020 at "Organic chemistry frontiers"
DOI: 10.1039/d0qo00007h
Abstract: In this communication, we disclosed a palladium-catalyzed carbonylative procedure for the synthesis of 1-aroyl-3-aryl-1,5-dihydro-2H-pyrrol-2-ones from propargyl amines and aryl halides. By using TFBen as the CO source, the reaction provides a facile and straightforward access… read more here.
Keywords: propargyl amines; aryl dihydro; dihydro pyrrol; palladium catalyzed ... See more keywords
Cu-Catalyzed decarboxylative annulation of N-substituted glycines with 3-formylchromones: synthesis of functionalized chromeno[2,3-b]pyrrol-4(1H)-ones.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc03816a
Abstract: A novel protocol was developed for preparing functionalized chromeno[2,3-b]pyrrol-4(1H)-ones 3 (CMPOs) from 3-formylchromones with N-substituted glycine derivatives. The method entailed decarboxylative annulation of the acyl group of 3-formylchromones by simply heating a mixture of substrates… read more here.
Keywords: decarboxylative annulation; chromeno pyrrol; functionalized chromeno; catalyzed decarboxylative ... See more keywords
Potash Alum as a Sustainable Heterogeneous Catalyst: A One-Pot Efficient Synthesis of Highly Functionalized Pyrrol-2-ones and Furan-2-ones
Sign Up to like & getrecommendations! Published in 2020 at "Polycyclic Aromatic Compounds"
DOI: 10.1080/10406638.2020.1768415
Abstract: An environment-friendly efficient one-pot, multicomponent condensation of different aldehydes and amines with dialkyl acetylenedicarboxylates, for the synthesis of polysubstituted pyrrol-2-ones and... read more here.
Keywords: pyrrol ones; alum sustainable; potash alum; one pot ... See more keywords
Synthesis, biological evaluation and theoretical studies of (E)-1-(4-sulfamoyl-phenylethyl)-3-arylidene-5-aryl-1H-pyrrol-2(3H)-ones as human carbonic anhydrase inhibitors
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2023.2189126
Abstract: Abstract A series of 20 newly designed (E)-1-(4-sulphamoylphenylethyl)-3-arylidene-5-aryl-1H-pyrrol-2(3H)-ones was synthesised and assessed as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors towards four human isoforms of pharmaceutical interest, that is, hCA I, II, IX and XII. The… read more here.
Keywords: anhydrase inhibitors; carbonic anhydrase; aryl pyrrol; pyrrol ones ... See more keywords