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   Articles with "pyrrole imidazole" as a keyword



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N‐terminal Cationic Modification of Linear Pyrrole‐Imidazole Polyamide Improves Its Binding to DNA

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recommendations! Published in 2022 at "ChemBioChem"

DOI: 10.1002/cbic.202200124

Abstract: Pyrrole‐imidazole polyamides (PIPs) bind to double‐stranded DNA (dsDNA) with varied sequence selectivity. We synthesized linear PIPs that can bind to narrow minor grooves of polypurine/polypyrimidine sequences and target long recognition sequences but have lower molecular… read more here.

Keywords: pyrrole imidazole; modification linear; terminal cationic; cationic modification ... See more keywords
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Anticancer effect of a pyrrole‐imidazole polyamide‐triphenylphosphonium conjugate selectively targeting a common mitochondrial DNA cancer risk variant in cervical cancer cells

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recommendations! Published in 2022 at "International Journal of Cancer"

DOI: 10.1002/ijc.34319

Abstract: Cervical cancer remains a major threat to women's health, especially in countries with limited medical resources, and new drugs are needed to improve patient survival and minimize adverse effects. Here, we examine the effects of… read more here.

Keywords: cervical cancer; pyrrole imidazole; cancer risk; imidazole polyamide ... See more keywords
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Antiviral activity of pyrrole‐imidazole polyamides against SV40 and BK polyomaviruses

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recommendations! Published in 2018 at "Antiviral Research"

DOI: 10.1016/j.antiviral.2018.02.012

Abstract: ABSTRACT The ability of antiviral polyamides (AVP) to act upon polyomaviruses (PyV) was evaluated. Initial studies found that a single treatment of AVP protected SV40‐infected BSC‐1 cells from cytopathic effect (CPE) for as long as… read more here.

Keywords: sv40 polyomaviruses; antiviral activity; activity pyrrole; pyrrole imidazole ... See more keywords

Chemical Information and Computational Modeling of Targeting Hybrid Nucleic Acid Structures of PIM1 Sequences by Synthetic Pyrrole-Imidazole Carboxamide Drugs

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recommendations! Published in 2022 at "Journal of chemical information and modeling"

DOI: 10.1021/acs.jcim.1c01500

Abstract: DNA can adopt various distinct structural motifs, such as quadruplex, duplex, i-motifs, etc. which have multifarious applications in biomedical therapeutics. Quadruplex-duplex hybrids (QDHs) consist of the juxtaposed quadruplex and duplex motifs and are thermally stable… read more here.

Keywords: information; pyrrole imidazole; quadruplex duplex; pim1 sequences ... See more keywords

Potentiometric Determination of Acid Dissociation Constants (pK a) for an Anticancer Pyrrole-Imidazole Polyamide.

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recommendations! Published in 2022 at "ACS medicinal chemistry letters"

DOI: 10.1021/acsmedchemlett.2c00348

Abstract: To optimize the pharmacological properties of an anticancer pyrrole-imidazole (Py-Im) polyamide (PIP-1), we characterized the acid dissociation constants of PIP-1, three other structurally related hairpin-shaped polyamides, and a cyclic polyamide bearing the same core sequence… read more here.

Keywords: dissociation constants; pyrrole imidazole; dissociation; acid dissociation ... See more keywords
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Control of Forward/Reverse Orientation Preference of Cyclic Pyrrole-Imidazole Polyamides.

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recommendations! Published in 2019 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.9b05516

Abstract: Pyrrole-imidazole polyamides (PIPs) bind to predetermined double-stranded DNA sequences and selectively target a large variety of DNA sequences. Although the forward-binding (5'-3'/N-C) orientation, in which the N-terminus of PIPs faces the 5'-terminus of DNAs, is… read more here.

Keywords: preference; orientation; forward reverse; orientation preference ... See more keywords

Suppression of NSCLC A549 tumor growth by a mtDNA mutation-targeting pyrrole-imidazole polyamide-TPP and a senolytic drug.

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recommendations! Published in 2022 at "Cancer science"

DOI: 10.1111/cas.15290

Abstract: Certain somatic mutations in mitochondrial DNA (mtDNA) were associated with tumor progression and frequently found in a homoplasmic state. We recently reported that pyrrole-imidazole polyamide conjugated with the mitochondria-delivering moiety triphenylphosphonium (PIP-TPP) targeting a mtDNA… read more here.

Keywords: tumor; nsclc a549; mtdna mutation; pyrrole imidazole ... See more keywords