Metabolic benefits of 1-(3-(4-(o-tolyl)piperazin-1-yl)propyl)pyrrolidin-2-one: a non-selective α-adrenoceptor antagonist
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-017-0779-7
Abstract: PurposePrevious studies have shown that several components of the metabolic syndrome, such as hypertension, obesity or imbalanced lipid and carbohydrate homeostasis, are associated with the sympathetic nervous system overactivity. Therefore, the inhibition of the adrenergic… read more here.
Keywords: non selective; pyrrolidin one; adrenoceptor; selective adrenoceptor ... See more keywords
Quantum chemical investigation of the formation of spiroheterocyclic compounds via the (3 + 2) cycloaddition reaction of 1-methyl-3-(2,2,2-trifluoroethylidene) pyrrolidin-2-one with diazomethane and nitrone derivatives
Sign Up to like & getrecommendations! Published in 2021 at "Tetrahedron"
DOI: 10.1016/j.tet.2021.132306
Abstract: Abstract The chemo-, regio- and stereoselectivities of the formation of spiroheterocycles via the (3 + 2) cycloaddition (32CA) reaction of 1-methyl-3-(2,2,2-trifluoroethylidene) pyrrolidin-2-one (A1) derivatives with diazomethane and nitrone derivative have been studied at the M06–2X/6-311G level of… read more here.
Keywords: trifluoroethylidene pyrrolidin; reaction methyl; pyrrolidin one; nitrone ... See more keywords
Novel benzylated (pyrrolidin-2-one) / (imidazolidin-2-one) derivatives as potential Anti-Alzheimer's agents: Synthesis and Pharmacological investigations.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00403
Abstract: A series of N-benzylated (pyrrolidin-2-one) / (imidazolidin-2-one) derivatives were synthesized and evaluated for anti-Alzheimer's activity. The analogs were designed and synthesized based on lead compound donepezil, which is currently prescribed as a major drug for… read more here.
Keywords: benzylated pyrrolidin; one imidazolidin; pyrrolidin one; imidazolidin one ... See more keywords
The Antiarrhythmic and Hypotensive Effects of S-61 and S-73, the Pyrrolidin-2-one Derivatives with α1-Adrenolytic Properties
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231810381
Abstract: Heart rhythm abnormalities are a cause of many deaths worldwide. Unfortunately, the available antiarrhythmic drugs show limited efficacy and proarrhythmic potential. Thus, efforts should be made to search for new, more effective, and safer pharmacotherapies.… read more here.
Keywords: adrenolytic properties; hypotensive effects; one derivatives; induced arrhythmia ... See more keywords