Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104507
Abstract: In a sustained search for novel α-amylase inhibitors for the treatment of type 2 diabetes mellitus (T2DM), we report herein the synthesis of a series of nineteen novel rhodanine-fused spiro[pyrrolidine-2,3'-oxindoles]. They were obtained by one-pot… read more here.
Keywords: rhodanine; novel amylase; amylase inhibitors; study ... See more keywords
Studies on the phase I metabolites of the new designer drug 1-(2,3-dihydro-1H-inden-5-yl)-2-(pyrrolidine-1-yl)butan-1-one (5-PPDI) in human urine.
Sign Up to like & getrecommendations! Published in 2020 at "Forensic science international"
DOI: 10.1016/j.forsciint.2020.110214
Abstract: Pyrrolidinophenones (PPs) are synthetic cathinones containing a pyrrolidine ring that are used recreationally worldwide. Recently, many studies on the metabolism and cytotoxicity of PPs have been published. Here, we focus on new designer drug containing… read more here.
Keywords: new designer; dihydro inden; designer drug; pyrrolidine ... See more keywords
New spiro-linked indolinone pyrrolidine selenoxoimidazolones
Sign Up to like & getrecommendations! Published in 2020 at "Mendeleev Communications"
DOI: 10.1016/j.mencom.2020.05.020
Abstract: New 2-selenoxodispiro[imidazolidine-4,3′-pyrrolidine-4′,3″-indoline]-2″,5-dione system was accessed by addition of azomethine ylide at the double bond of (Z)-(2-oxoindolin-3-ylidene)-2-selenoxoimidazolidin-4-one derivatives. The latter were stereoselectively obtained in two steps from ethyl isoselenocyanatoacetate and isatins. read more here.
Keywords: pyrrolidine selenoxoimidazolones; linked indolinone; indolinone pyrrolidine; pyrrolidine ... See more keywords
N-Phosphorylated Pyrrolidines: An Overview of Synthetic Approaches
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DOI: 10.1055/s-0039-1690889
Abstract: Organophosphorus pyrrolidine derivatives possessing P–N bonds are a promising yet underexplored class of compounds. In this short review we overview the general approaches to these compounds described so far, with a special emphasis on their… read more here.
Keywords: pyrrolidines overview; pyrrolidine based; pyrrolidine; phosphorylated pyrrolidines ... See more keywords
A density functional theory-based analysis of the structural, topological and electronic properties of gemcitabine drug adsorption on the pyrrolidine functionalized single-walled carbon nanotube
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2018.1491892
Abstract: Abstract The stability of gemcitabine anticancer drug on the functionalized (8,0) zigzag carbon nanotube as a drug delivery vehicle is studied within the formalism of the density functional theory calculations to understand the role of… read more here.
Keywords: gemcitabine drug; theory; carbon nanotube; drug ... See more keywords
Multivalent Pyrrolidine Iminosugars: Synthesis and Biological Relevance
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27175420
Abstract: Recently, the strategy of multivalency has been widely employed to design glycosidase inhibitors, as glycomimetic clusters often induce marked enzyme inhibition relative to monovalent analogs. Polyhydroxylated pyrrolidines, one of the most studied classes of iminosugars,… read more here.
Keywords: synthesis biological; pyrrolidine iminosugars; iminosugars synthesis; pyrrolidine ... See more keywords
Synthesis of pyrrolidine-based hamamelitannin analogues as quorum sensing inhibitors in Staphylococcus aureus
Sign Up to like & getrecommendations! Published in 2018 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.14.260
Abstract: Interfering with bacterial cell-to-cell communication is a promising strategy to combat antimicrobial resistance. The natural product hamamelitannin and several of its analogues have been identified as quorum sensing inhibitors. In this paper the synthesis of… read more here.
Keywords: synthesis pyrrolidine; pyrrolidine based; hamamelitannin; quorum sensing ... See more keywords