Advanced Pyrrolidine‐Carbamate Self‐Immolative Spacer with Tertiary Amine Handle Induces Superfast Cyclative Drug Release
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DOI: 10.1002/cmdc.202200279
Abstract: Amine‐carbamate self‐immolative (SI) spacers represent practical and versatile tools in targeted prodrugs, but their slow degradation mechanism limits drug activation at the site of disease. We engineered a pyrrolidine‐carbamate SI spacer with a tertiary amine… read more here.
Keywords: pyrrolidine carbamate; self immolative; spacer; spacer tertiary ... See more keywords