Synthesis and Determination of Lipophilicity, Anticonvulsant Activity, and Preliminary Safety of 3‐Substituted and 3‐Unsubstituted N‐[(4‐Arylpiperazin‐1‐yl)alkyl]pyrrolidine‐2,5‐dione Derivatives
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DOI: 10.1002/cmdc.201700539
Abstract: A new series of 1,3‐substituted pyrrolidine‐2,5‐dione derivatives as potential anticonvulsant agents are described. Initial pharmacological screening of these compounds was performed by using acute models of seizures (MES and scPTZ tests) in mice after intraperitoneal… read more here.
Keywords: pyrrolidine dione; dione; lipophilicity; dione derivatives ... See more keywords
Synthesis, in-vitro α-glucosidase inhibition, antioxidant, in-vivo antidiabetic and molecular docking studies of pyrrolidine-2,5-dione and thiazolidine-2,4-dione derivatives.
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DOI: 10.1016/j.bioorg.2019.103128
Abstract: α-Glucosidase is considered as a therapeutic target for the treatment of type 2 diabetes mellitus (DM2). In current study, we synthesized pyrrolidine-2,5-dione (succinimide) and thiazolidine-2,4-dione derivatives and evaluated for their ability to inhibit α-Glucosidase. Pyrrolidine-2,5-dione… read more here.
Keywords: pyrrolidine dione; dione; thiazolidine dione; dione derivatives ... See more keywords
Novel pyrrolidine-2,4-dione derivatives containing pharmacophores of both hydrazine and diphenyl ether as potential antifungal agents: design, synthesis, biological evaluation, and 3D-QSAR study
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DOI: 10.1039/d0nj04551a
Abstract: In order to screen novel fungicide leads, 19 pyrrolidine-2,4-dione derivatives containing the pharmacophores of both hydrazine and diphenyl ether were designed, synthesized, and characterized by FT-IR, 1H NMR, 13C NMR, and HR-MS. The obtained target… read more here.
Keywords: pyrrolidine dione; containing pharmacophores; derivatives containing; hydrazine diphenyl ... See more keywords