Discovery of Spiro[pyrrolidine-3,3'-oxindole] LXRβ Agonists for the Treatment of Osteoporosis.
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DOI: 10.1021/acs.jmedchem.2c01661
Abstract: Osteoclasts have an additional demand for cholesterol compared to normal cells. Liver X receptors (LXRs) are famous for regulation of lipid and cholesterol metabolism. Therefore, we propose that the LXR β agonist can regulate the… read more here.
Keywords: pyrrolidine oxindole; lxr agonists; spiro pyrrolidine; osteoporosis ... See more keywords