Introduction of pyrrolidineoxy or piperidineamino group at the 4-position of quinazoline leading to novel quinazoline-based phosphoinositide 3-kinase delta (PI3Kδ) inhibitors
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DOI: 10.1080/14756366.2018.1444608
Abstract: Abstract Phosphoinositide 3-kinase Delta (PI3Kδ) plays a key role in B-cell signal transduction and inhibition of PI3Kδ was confirmed to have clinical benefit in certain types of activation of B-cell malignancies. Herein, we reported a… read more here.
Keywords: quinazoline; kinase delta; pi3k; pyrrolidineoxy piperidineamino ... See more keywords