Mechanistic Studies on the Synthesis of Pyrrolidines and Piperidines via Copper-Catalyzed Intramolecular C–H Amination
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DOI: 10.1021/acs.organomet.2c00095
Abstract: We have recently developed a method for the synthesis of pyrrolidines and piperidines via intramolecular C–H amination of N-fluoride amides using [TpxCuL] complexes as precatalysts [Tpx = tris(pyrazolyl)borate ligand and L = THF or CH3CN].… read more here.
Keywords: copper; pyrrolidines piperidines; mechanistic studies; piperidines via ... See more keywords
Regio- and Stereoselective Palladium-Catalyzed C(sp3)-H Arylation of Pyrrolidines and Piperidines with C(3) Directing Groups.
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DOI: 10.1021/acs.orglett.8b01521
Abstract: The selective synthesis of cis-3,4-disubstituted pyrrolidines and piperidines is achieved by a Pd-catalyzed C-H arylation with excellent regio- and stereoselectivity using an aminoquinoline auxiliary at C(3). The arylation conditions are silver free, use a low… read more here.
Keywords: pyrrolidines piperidines; catalyzed sp3; stereoselective palladium; arylation ... See more keywords
Pyrrolidines and piperidines bearing chiral tertiary alcohols by nickel-catalyzed enantioselective reductive cyclization of N-alkynones
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DOI: 10.1038/s42004-018-0092-1
Abstract: Pyrrolidines and piperidines are important building blocks in organic synthesis. Numerous methods exist for constructing substituted pyrrolidines and piperidines. However, efficient syntheses of pyrrolidines and piperidines bearing chiral tertiary alcohols are limited. Here we report… read more here.
Keywords: pyrrolidines piperidines; tertiary alcohols; cyclization; chiral tertiary ... See more keywords
Palladium/GF-Phos-catalyzed asymmetric carbenylative amination to access chiral pyrrolidines and piperidines
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DOI: 10.1039/d2sc03999k
Abstract: The cross-coupling of N-tosylhydrazones has emerged as a powerful method for the construction of structurally diverse molecules, but the development of catalytic enantioselective versions still poses considerable challenges and only very limited examples have been… read more here.
Keywords: palladium phos; pyrrolidines piperidines; chiral pyrrolidines; phos catalyzed ... See more keywords