One-Pot Synthesis of N-(Phosphorylmethyl)Pyrrolidines via Acid-Catalyzed Cascade Elimination/Cyclization/Friedel–Crafts Reaction
Sign Up to like & getrecommendations! Published in 2020 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-020-02697-2
Abstract: The efficient approach to novel water-soluble 2-aryl-substituted N-(phosphorylmethyl)pyrrolidines via acid-catalyzed elimination/cyclization/Friedel–Crafts reaction sequence of {[(4,4-diethoxybutyl)amino]methyl}phosphonates is proposed. Zwitterionic structure of N-(phosphorylmethyl) pyrrolidines has been proved by X-ray crystallography. read more here.
Keywords: phosphorylmethyl pyrrolidines; elimination cyclization; cyclization friedel; pyrrolidines via ... See more keywords
Asymmetric Synthesis of Pyrrolidines via Oxetane Desymmetrization.
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DOI: 10.1021/acs.orglett.2c00564
Abstract: Asymmetric synthesis of chiral pyrrolidines bearing an all-carbon quaternary stereocenter in the 3-position remains challenging. Herein we report two efficient protocols by means of oxetane desymmetrization, featuring the use of a readily available tert-butylsulfinamide chiral… read more here.
Keywords: pyrrolidines via; oxetane desymmetrization; asymmetric synthesis; synthesis pyrrolidines ... See more keywords
Polycyclic Azetidines and Pyrrolidines via Palladium-Catalyzed Intramolecular Amination of Unactivated C(sp3)-H Bonds.
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DOI: 10.1021/acs.orglett.7b02339
Abstract: A novel strategy to construct complex polycyclic nitrogen-containing heterocycles from aliphatic amines via picolinamide-assisted palladium-catalyzed C-H bond activation reaction was reported. The reaction exhibits broad substrate scope for the synthesis of various azabicyclic scaffolds, including… read more here.
Keywords: via palladium; polycyclic azetidines; palladium catalyzed; pyrrolidines via ... See more keywords