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Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103658
Abstract: A novel set of pyrrolidinone-based chlorinated benzenesulfonamide derivatives were synthesized and investigated for their binding affinity and selectivity against recombinant human carbonic anhydrases I-XIV using fluorescent thermal shift, p-nitrophenyl acetate hydrolysis and stopped-flow enzymatic inhibition…
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Keywords:
affinity relationship;
human carbonic;
affinity;
pyrrolidinone ... See more keywords
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Published in 2020 at "Pesticide biochemistry and physiology"
DOI: 10.1016/j.pestbp.2020.104684
Abstract: As important chemical pesticides, protoporphyrinogen oxidase (PPO, EC 1.3.3.4) herbicides play a vital role in weed management. Herein, in a search for novel PPO herbicides, a series of phenoxypyridine-2-pyrrolidinone derivatives were synthesized and their herbicidal…
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Keywords:
protoporphyrinogen oxidase;
pyrrolidinone;
phenoxy trifluoromethyl;
compound ... See more keywords
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Published in 2018 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.8b00650
Abstract: Two novel flavoalkaloids, (-)-6-(5'''- S)- N-ethyl-2-pyrrolidinone-epigallocatechin- O-gallate (ester-type catechin pyrrolidinone A, etc-pyrrolidinone A, 1), (-)-6-(5'''- R)- N-ethyl-2-pyrrolidinone-epigallocatechin- O-gallate (etc-pyrrolidinone B, 2), and new naturally occurring flavoalkaloids, (-)-8- N-ethyl-2-pyrrolidinone-epigallocatechin- O-gallate (etc-pyrrolidinone C, 3a, and etc- pyrrolidinone…
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Keywords:
formation advanced;
pyrrolidinone;
novel flavoalkaloids;
epigallocatechin gallate ... See more keywords
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Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b00687
Abstract: Propargylation of Ugi adducts under the addition of excess sodium hydride in DMSO leads to direct formation of pyrrolidinone enamides, which are useful precursors of iminium intermediates and may be trapped by various nucleophiles. This…
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Keywords:
propargylation;
pyrrolidinone;
benzoindolizidine;
propargylation ugi ... See more keywords
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Published in 2023 at "Organic Chemistry Frontiers"
DOI: 10.1039/d3qo00544e
Abstract: Herein, a practical, convenient and facile protocol to construct highly functionalized 2-pyrrolidinone enabled by N-Heterocyclic Carbene(NHC)-catalyzed radical tandem cyclization has been developed (30 examples, up to 94% yield). This method...
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Keywords:
radical tandem;
catalyzed radical;
tandem cyclization;
pyrrolidinone ... See more keywords