Structure, biochemistry, and gene expression patterns of the proline biosynthetic enzyme pyrroline-5-carboxylate reductase (PYCR), an emerging cancer therapy target.
Sign Up to like & getrecommendations! Published in 2021 at "Amino acids"
DOI: 10.1007/s00726-021-02999-5
Abstract: Proline metabolism features prominently in the unique metabolism of cancer cells. Proline biosynthetic genes are consistently upregulated in multiple cancers, while the proline catabolic enzyme proline dehydrogenase has dual, context-dependent pro-cancer and pro-apoptotic functions. Furthermore,… read more here.
Keywords: biochemistry; pycr; cancer; pyrroline carboxylate ... See more keywords
Shikonin induces apoptosis and autophagy via downregulation of pyrroline-5-carboxylate reductase1 in hepatocellular carcinoma cells
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2052673
Abstract: ABSTRACT Shikonin(SK) is a natural small molecule naphthoquinone compound, which has anti-cancer activity in various human malignant tumors. Pyrroline-5-carboxylate reductase 1(PYCR1) is involved in tumorigenesis and regulates various cellular processes, including growth, invasion, migration, and… read more here.
Keywords: hepatocellular carcinoma; pycr1; pyrroline carboxylate; apoptosis autophagy ... See more keywords
Carbon and nitrogen remobilization during seed filling is strongly impaired in pyrroline-5-carboxylate dehydrogenase mutant.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of experimental botany"
DOI: 10.1093/jxb/erac499
Abstract: Proline is an amino acid which is degraded in the mitochondrion by the sequential action of Proline Dehydrogenase (ProDH) and Pyrroline-5-Carboxylate Dehydrogenase (P5CDH) to form glutamate. We investigated the phenotypes of Arabidopsis wildtype plants, knockout… read more here.
Keywords: carbon nitrogen; carboxylate dehydrogenase; pyrroline carboxylate; remobilization ... See more keywords
Functional Characterization of Four Putative δ1-Pyrroline-5-Carboxylate Reductases from Bacillus subtilis
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2017.01442
Abstract: In most living organisms, the amino acid proline is synthesized starting from both glutamate and ornithine. In prokaryotes, in the absence of an ornithine cyclodeaminase that has been identified to date only in a small… read more here.
Keywords: bacillus subtilis; p5c reductase; pyrroline carboxylate;
The Δ1-pyrroline-5-carboxylate synthetase family performs diverse physiological functions in stress responses in pear (Pyrus betulifolia)
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.1066765
Abstract: Δ1-Pyrroline-5-carboxylate synthetase (P5CS) acts as the rate-limiting enzyme in the biosynthesis of proline in plants. Although P5CS plays an essential role in plant responses to environmental stresses, its biological functions remain largely unclear in pear… read more here.
Keywords: stress; family; pbp5cs genes; carboxylate synthetase ... See more keywords