Synthesis and Evaluation of Voltage‐Gated Sodium Channel Blocking Pyrroline Derivatives Endowed with Both Antiarrhythmic and Antioxidant Activities
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DOI: 10.1002/cmdc.202000692
Abstract: Under the hypothesis that cardioprotective agents might benefit from synergism between antiarrhythmic activity and antioxidant properties, a small series of mexiletine analogues were coupled with the 2,2,5,5‐tetramethylpyrroline moiety, known for its antioxidant effect, in order… read more here.
Keywords: sodium channel; pyrroline derivatives; synthesis evaluation; evaluation voltage ... See more keywords