In vitro biotransformation of pyrrolizidine alkaloids in different species. Part I: Microsomal degradation
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DOI: 10.1007/s00204-017-2114-7
Abstract: Pyrrolizidine alkaloids (PA) are secondary metabolites of certain flowering plants. The ingestion of PAs may result in acute and chronic effects in man and livestock with hepatotoxicity, mutagenicity, and carcinogenicity being identified as predominant effects.… read more here.
Keywords: degradation; pyrrolizidine; pyrrolizidine alkaloids; alkaloids different ... See more keywords
Senecio angustifolius as the major source of pyrrolizidine alkaloid contamination of rooibos tea (Aspalathus linearis)
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DOI: 10.1016/j.sajb.2017.01.013
Abstract: Abstract Pyrrolizidine alkaloids (PAs) and their N-oxides (PANOs) were detected in commercial rooibos tea which resulted in an investigation into the source of the contamination. Field studies showed that Senecio angustifolius occurs as a common… read more here.
Keywords: pyrrolizidine; rooibos tea; source; aspalathus linearis ... See more keywords
Epoxides as Precursors to 1-Hydroxymethyl Indolizidine and Pyrrolizidine
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DOI: 10.1055/s-0036-1588173
Abstract: Herein we describe the synthesis of 1-hydroxymethyl pyrrolizidine and indolizidine alkaloids from epoxy-tethered pyrrole precursors. Two titanium-based methods are evaluated for the construction of the bicyclic scaffold: the Lewis acid mediated cyclization developed by Tanis… read more here.
Keywords: hydroxymethyl indolizidine; pyrrolizidine; indolizidine pyrrolizidine; epoxides precursors ... See more keywords
An Intramolecular Hydroaminomethylation-Based Approach to Pyrrolizidine Alkaloids under Microwave-Assisted Heating
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DOI: 10.3390/molecules27154762
Abstract: A general method for the synthesis of pyrrolizidine derivatives using an intramolecular hydroaminomethylation protocol (HAM) under microwave (MW) dielectric heating is reported. Starting from a 3,4-bis(benzyloxy)-2-[(benzyloxy)methyl]-5-vinylpyrrolidine, MW-assisted intramolecular HAM in the presence of gaseous H2… read more here.
Keywords: intramolecular hydroaminomethylation; heating; pyrrolizidine; hydroaminomethylation based ... See more keywords