Pyrrolo‐Fused Phenanthridines as Potential Anticancer Agents: Synthesis, Prediction, and Biological Evaluation
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70443
Abstract: We report the synthesis of four novel monoquaternary salts and four fused pyrrolo‐phenanthridine compounds, fully characterized by NMR, FT‐IR, and mass spectrometry. Guided by theoretical predictions, including molecular docking studies, we assessed their cytotoxic activity… read more here.
Keywords: potential anticancer; anticancer; pyrrolo; pyrrolo fused ... See more keywords
Isolation, chemistry, and biology of pyrrolo[1,4]benzodiazepine natural products.
Sign Up to like & getrecommendations! Published in 2021 at "Medicinal research reviews"
DOI: 10.1002/med.21803
Abstract: The isolation of the antitumor antibiotic anthramycin in the 1960s prompted extensive research into pyrrolo[1,4]benzodiazepines (PBD) as potential therapeutics for the treatment of cancers. Since then, nearly 60 PBD natural products have been isolated and… read more here.
Keywords: natural products; pyrrolo; isolation chemistry; chemistry ... See more keywords
Novel π-extended pyrrolo[1,2-a]pyrazinoporphyrins: Synthesis, photophysical properties and mercuric ion recognition
Sign Up to like & getrecommendations! Published in 2018 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2018.01.041
Abstract: Abstract A modified Pictet-Spengler protocol has been applied to synthesize novel π-extended copper(II) pyrrolo[1,2-a]pyrazinoporphyrins in good yields at 25 °C by using p-dodecylbenzenesulfonic acid as Bronsted acid catalyst. On demetallation in the presence of concentrated sulfuric… read more here.
Keywords: novel extended; pyrrolo; properties mercuric; mercuric ion ... See more keywords
Design and synthesis of novel pyrrolo[2,3-a]carbazoles: 7-Chloro-2-oxo-3a-(2'-oxo-2',3'-dihydro-1'H-indol-3'-yl)-2,3,3a,4,5,10-hexahydro-pyrrolo[3,2-a]carbazole-1-carbonitrile as an efficient anticancer agent.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.03.056
Abstract: Highly efficient poly functionalized pyrrolo[3,2-a]carbazoles via ring contraction through rearrangement and intramolecular Michael addition reaction using one pot multicomponent reaction (MCR) is reported for the first time. Free radical scavenging and anticancer activities were determined… read more here.
Keywords: pyrrolo carbazoles; pyrrolo; chloro oxo; anticancer ... See more keywords
Catalytic Asymmetric [3 + 2] Annulation via Indolyl Copper-Allenylidene Intermediates: Diastereo- and Enantioselective Assembly of Pyrrolo[1,2-a]indoles.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c01594
Abstract: A catalytic asymmetric decarboxylative [3 + 2] annulation via indolyl copper-allenylidene amphiphilic intermediates has been developed. This protocol offers a straightforward method for the synthesis of biologically important pyrrolo[1,2-a]indoles bearing contiguous quaternary and tertiary stereogenic… read more here.
Keywords: pyrrolo; pyrrolo indoles; annulation via; indolyl copper ... See more keywords
Controllable Defluorinative Cyclization for Divergent Synthesis of Pyrrolo[2,3-d]pyrimidines and Fluorinated Pyrimidines from β-CF3-1,3-Enynes and Amidine Hydrochlorides.
Sign Up to like & getrecommendations! Published in 2025 at "Organic letters"
DOI: 10.1021/acs.orglett.5c02345
Abstract: This study successfully developed a novel controllable defluorinative cyclization strategy for β-CF3-1,3-enynes, achieving the divergent synthesis of pyrrolo[2,3-d]pyrimidines and fluorinated pyrimidines. The reaction between β-CF3-1,3-enynes and amidine hydrochlorides at a 1:2 molar ratio triggered selective… read more here.
Keywords: pyrrolo; divergent synthesis; defluorinative cyclization; cf3 enynes ... See more keywords
Stepwise cycloaddition reaction of N-phenacylbenzothiazolium bromides and nitroalkenes for tetrahydro-, dihydro- and benzo[d]pyrrolo[2,1-b]thiazoles
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DOI: 10.1038/srep46470
Abstract: The triethylamine promoted stepwise 1,3-dipolar cycloaddition reaction of N-phenacylbenzothiazolium bromides with nitroalkenes in ethanol resulted in a mixture of two isomeric tetrahydrobenzo[d]pyrrolo[2,1-b]thiazoles with cis/trans/cis- and all-trans-configurations. More importantly, the corresponding dihydrobenzo[d]pyrrolo[2,1-b]thiazoles can be selectively prepared… read more here.
Keywords: pyrrolo; reaction phenacylbenzothiazolium; benzo pyrrolo; pyrrolo thiazoles ... See more keywords
FeCl3-Catalyzed synthesis of pyrrolo[1,2-a]quinoxaline derivatives from 1-(2-aminophenyl)pyrroles through annulation and cleavage of cyclic ethers.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc07089f
Abstract: A straightforward Fe-catalyzed method for the synthesis of pyrrolo[1,2-a]quinoxalines from 1-(2-aminophenyl)pyrroles and cyclic ethers, which includes functionalization of C(sp3)-H bonds and the construction of C-C and C-N bonds, has been developed. The features of this… read more here.
Keywords: aminophenyl pyrroles; synthesis pyrrolo; pyrrolo; cyclic ethers ... See more keywords
Tungstic acid-functionalized MCM-41 as a novel mesoporous solid acid catalyst for the one-pot synthesis of new pyrrolo[2,1-a]isoquinolines
Sign Up to like & getrecommendations! Published in 2018 at "New Journal of Chemistry"
DOI: 10.1039/c8nj02699h
Abstract: Tungstic acid-functionalized MCM-41 (MCM-41–HWO4) was prepared, characterized and applied as a reusable mesoporous catalyst for the one-pot synthesis of new pyrrolo[2,1-a]isoquinoline derivatives. The characterization was performed using FT-IR, X-ray diffraction patterns (XRD), scanning electron microscopy… read more here.
Keywords: catalyst; acid functionalized; functionalized mcm; tungstic acid ... See more keywords
One pot synthesis of pyrrolo[3,2,1-de]phenanthridines from 7-phenylindoles via tandem C–H olefination/aza-Michael addition
Sign Up to like & getrecommendations! Published in 2020 at "Organic chemistry frontiers"
DOI: 10.1039/c9qo01135h
Abstract: An unprecedented one-pot C–H olefination/aza-Michael addition tandem process has been developed for the synthesis of pyrrolo[3,2,1-de]phenanthridines from 7-phenylindoles and alkenes using a [Cp*RhCl2]2/AgOAc/Me4NOAc catalytic system. A relatively wide range of functional groups are tolerated, and… read more here.
Keywords: olefination aza; pyrrolo phenanthridines; pyrrolo; michael addition ... See more keywords
Synthesis of pyrrolo[3,4-c]pyridines via metal-free cross-coupling/cyclization cascades of β-ketothioamides with 2-aroylmalononitrile at room temperature.
Sign Up to like & getrecommendations! Published in 2025 at "Chemical communications"
DOI: 10.1039/d5cc04230e
Abstract: We herein report a metal-free, chemo- and site-selective strategy to synthesize pyrrolo[3,4-c]pyridines using β-ketothioamides and 2-aroylmalononitrile at room temperature in open air. The base-assisted approach proceeds through cross-coupling/two-fold intramolecular cyclization cascades enabling direct access to… read more here.
Keywords: metal free; pyrrolo pyridines; pyrrolo; aroylmalononitrile room ... See more keywords