Novel pyrrolo[2,1-c][1,4]benzodiazepine-3,11-dione (PBD) derivatives as selective HDAC6 inhibitors to suppress tumor metastasis and invasion in vitro and in vivo.
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DOI: 10.1016/j.bioorg.2021.105081
Abstract: Selective inhibition of histone deacetylase 6 (HDAC6) has been emerged as a promising approach to cancer treatment. As a pivotal strategy for drug discovery,molecular hybridization was introduced in this study and a series of pyrrolo[2,1-c][1,4]… read more here.
Keywords: hdac6 inhibitors; vitro vivo; metastasis; selective hdac6 ... See more keywords